2-Acetylamino-2-(1-benzenesulfonyl-5-bromo-1H-indol-3-ylmethyl)-malonic acid diethyl ester

Base Information

Chemical Name:2-Acetylamino-2-(1-benzenesulfonyl-5-bromo-1H-indol-3-ylmethyl)-malonic acid diethyl ester
CAS No.:151417-97-9
Molecular Formula:C₂₄H₂₅BrN₂O₇S
Molecular Weight:565.442
Hs Code.:

Synonyms:2-Acetylamino-2-(1-benzenesulfonyl-5-bromo-1H-indol-3-ylmethyl)-malonic acid diethyl ester

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Chemical Property of 2-Acetylamino-2-(1-benzenesulfonyl-5-bromo-1H-indol-3-ylmethyl)-malonic acid diethyl ester

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Technology Process of 2-Acetylamino-2-(1-benzenesulfonyl-5-bromo-1H-indol-3-ylmethyl)-malonic acid diethyl ester

There total 5 articles about 2-Acetylamino-2-(1-benzenesulfonyl-5-bromo-1H-indol-3-ylmethyl)-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10075-48-6
5-bromo-3-methyl-1H-indole

: 151417-97-9
2-Acetylamino-2-(1-benzenesulfonyl-5-bromo-1H-indol-3-ylmethyl)-malonic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, RT, 2 h, 2.) THF, 4 h

2: 96 percent / N-bromosuccinimide, benzoyl peroxide / CCl₄ / 3 h / Heating

3: 1.) NaH / 1.) THF, 0 deg C, 2.) THF, from 55 deg C to 60 deg C, 5 h

With N-Bromosuccinimide; n-butyllithium; Perbenzoic acid; sodium hydride; In tetrachloromethane;
DOI:10.1080/00397919308009861

Reference yield:

: 70070-22-3
5-bromo-3-methyl-1H-indole-2-carboxylic acid ethyl ester

: 151417-97-9
2-Acetylamino-2-(1-benzenesulfonyl-5-bromo-1H-indol-3-ylmethyl)-malonic acid diethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) aq. KOH, 2.) quinoline / 1.) EtOH, reflux, 12h, 2.) reflux, 2 h

2: 1.) n-BuLi / 1.) THF, RT, 2 h, 2.) THF, 4 h

3: 96 percent / N-bromosuccinimide, benzoyl peroxide / CCl₄ / 3 h / Heating

4: 1.) NaH / 1.) THF, 0 deg C, 2.) THF, from 55 deg C to 60 deg C, 5 h

With quinoline; potassium hydroxide; N-Bromosuccinimide; n-butyllithium; Perbenzoic acid; sodium hydride; In tetrachloromethane;
DOI:10.1080/00397919308009861

Reference yield:

: 622-88-8,41931-18-4
4-bromophenylhydrazine hydrochloride

: 151417-97-9
2-Acetylamino-2-(1-benzenesulfonyl-5-bromo-1H-indol-3-ylmethyl)-malonic acid diethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / conc. H₂SO₄ / ethanol / 8 h / Heating

2: 1.) aq. KOH, 2.) quinoline / 1.) EtOH, reflux, 12h, 2.) reflux, 2 h

3: 1.) n-BuLi / 1.) THF, RT, 2 h, 2.) THF, 4 h

4: 96 percent / N-bromosuccinimide, benzoyl peroxide / CCl₄ / 3 h / Heating

5: 1.) NaH / 1.) THF, 0 deg C, 2.) THF, from 55 deg C to 60 deg C, 5 h

With quinoline; potassium hydroxide; N-Bromosuccinimide; n-butyllithium; Perbenzoic acid; sulfuric acid; sodium hydride; In tetrachloromethane; ethanol;
DOI:10.1080/00397919308009861