N-(7-bromo-3-chloro-5',6'-dihydrospiro[chromeno[2,3-c]pyridine-5,4'-[1,3]thiazin]-2'-yl)-4-nitrobenzamide hydrochloride

Base Information

Chemical Name:N-(7-bromo-3-chloro-5',6'-dihydrospiro[chromeno[2,3-c]pyridine-5,4'-[1,3]thiazin]-2'-yl)-4-nitrobenzamide hydrochloride
CAS No.:1335218-84-2
Molecular Formula:C₂₂H₁₄BrClN₄O₄S*ClH
Molecular Weight:582.261
Hs Code.:

Synonyms:N-(7-bromo-3-chloro-5',6'-dihydrospiro[chromeno[2,3-c]pyridine-5,4'-[1,3]thiazin]-2'-yl)-4-nitrobenzamide hydrochloride

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Chemical Property of N-(7-bromo-3-chloro-5',6'-dihydrospiro[chromeno[2,3-c]pyridine-5,4'-[1,3]thiazin]-2'-yl)-4-nitrobenzamide hydrochloride

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Technology Process of N-(7-bromo-3-chloro-5',6'-dihydrospiro[chromeno[2,3-c]pyridine-5,4'-[1,3]thiazin]-2'-yl)-4-nitrobenzamide hydrochloride

There total 9 articles about N-(7-bromo-3-chloro-5',6'-dihydrospiro[chromeno[2,3-c]pyridine-5,4'-[1,3]thiazin]-2'-yl)-4-nitrobenzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1335218-83-1
N-(7-bromo-3-chloro-5-(2-hydroxyethyl)-5H-chromeno[2,3-c]pyridin-5-ylcarbamothioyl)-4-nitrobenzamide

: 1335218-84-2
N-(7-bromo-3-chloro-5',6'-dihydrospiro[chromeno[2,3-c]pyridine-5,4'-[1,3]thiazin]-2'-yl)-4-nitrobenzamide hydrochloride

Guidance literature:: With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; In dichloromethane; at 20 ℃; for 8h;

Reference yield:

: 1335218-72-8
ethyl 2-(7-bromo-3-chloro-5-hydroxy-5H-chromeno[2,3-c]pyridin-5-yl)acetate

: 1335218-84-2
N-(7-bromo-3-chloro-5',6'-dihydrospiro[chromeno[2,3-c]pyridine-5,4'-[1,3]thiazin]-2'-yl)-4-nitrobenzamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: trimethylsilylazide; boron trifluoride diethyl etherate / toluene / 16 h / 20 °C / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / 1.67 h / 0 - 20 °C / Inert atmosphere

3: tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

4: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 8 h / 20 °C

With lithium aluminium tetrahydride; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; trimethylsilylazide; boron trifluoride diethyl etherate; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 1335218-73-9
ethyl 2-(5-azido-7-bromo-3-chloro-5H-chromeno[2,3-c]pyridin-5-yl)acetate

: 1335218-84-2
N-(7-bromo-3-chloro-5',6'-dihydrospiro[chromeno[2,3-c]pyridine-5,4'-[1,3]thiazin]-2'-yl)-4-nitrobenzamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1.67 h / 0 - 20 °C / Inert atmosphere

2: tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 8 h / 20 °C

With lithium aluminium tetrahydride; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; In tetrahydrofuran; dichloromethane;