5-[hydroxy(p-iodophenyl)methyl]-5'-[hydroxy(p-tolyl)methyl]-2,2'-bithiophene

Base Information

• Chemical Name: 5-[hydroxy(p-iodophenyl)methyl]-5'-[hydroxy(p-tolyl)methyl]-2,2'-bithiophene
• CAS No.: 1276069-04-5
• Molecular Formula: C₂₃H₁₉IO₂S₂
• Molecular Weight: 518.439

Synonyms:5-[hydroxy(p-iodophenyl)methyl]-5'-[hydroxy(p-tolyl)methyl]-2,2'-bithiophene

Chemical Property of 5-[hydroxy(p-iodophenyl)methyl]-5'-[hydroxy(p-tolyl)methyl]-2,2'-bithiophene

Chemical Property:

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Technology Process of 5-[hydroxy(p-iodophenyl)methyl]-5'-[hydroxy(p-tolyl)methyl]-2,2'-bithiophene

There total 3 articles about 5-[hydroxy(p-iodophenyl)methyl]-5'-[hydroxy(p-tolyl)methyl]-2,2'-bithiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

5-[hydroxy(p-tolyl)methyl]-2,2'-bithiophene (1263319-69-2) + p-(iodophenyl)carboxaldehyde (15164-44-0) → 5-[hydroxy(p-iodophenyl)methyl]-5'-[hydroxy(p-tolyl)methyl]-2,2'-bithiophene (1276069-04-5)

Guidance literature:

5-[hydroxy(p-tolyl)methyl]-2,2'-bithiophene; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In diethyl ether; hexane; at 0 ℃; for 1h; Inert atmosphere;

p-(iodophenyl)carboxaldehyde; In diethyl ether; hexane; at 0 ℃; for 0.25h; Inert atmosphere;

DOI:10.1002/ejoc.201001482

Reference yield:

4-methyl-benzaldehyde (104-87-0) → 5-[hydroxy(p-iodophenyl)methyl]-5'-[hydroxy(p-tolyl)methyl]-2,2'-bithiophene (1276069-04-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / diethyl ether; hexane / 1 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / diethyl ether; hexane / 1 h / 0 °C / Inert atmosphere

2.2: 0.25 h / 0 °C / Inert atmosphere

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In diethyl ether; hexane;

DOI:10.1002/ejoc.201001482

Reference yield:

2,2'-Bithiophene (492-97-7) → 5-[hydroxy(p-iodophenyl)methyl]-5'-[hydroxy(p-tolyl)methyl]-2,2'-bithiophene (1276069-04-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / diethyl ether; hexane / 1 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / diethyl ether; hexane / 1 h / 0 °C / Inert atmosphere

2.2: 0.25 h / 0 °C / Inert atmosphere

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In diethyl ether; hexane;

DOI:10.1002/ejoc.201001482

upstream raw materials:

5-[hydroxy(p-tolyl)methyl]-2,2'-bithiophene

p-(iodophenyl)carboxaldehyde

2,2'-Bithiophene

4-methyl-benzaldehyde

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