5-(2-aminopyrimidin-5-yl)picolinic acid

Base Information

• Chemical Name: 5-(2-aminopyrimidin-5-yl)picolinic acid
• CAS No.: 1029715-33-0
• Molecular Formula: C₁₀H₈N₄O₂
• Molecular Weight: 216.199
• Mol file: 1029715-33-0.mol

Synonyms:5-(2-aminopyrimidin-5-yl)picolinic acid

Chemical Property of 5-(2-aminopyrimidin-5-yl)picolinic acid

Chemical Property:

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Technology Process of 5-(2-aminopyrimidin-5-yl)picolinic acid

There total 1 articles about 5-(2-aminopyrimidin-5-yl)picolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyrimidin-2-ylamine (402960-38-7) + methyl 5-bromopicolinate (29682-15-3) → 5-(2-aminopyrimidin-5-yl)picolinic acid (1029715-33-0)

Guidance literature:

5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyrimidin-2-ylamine; methyl 5-bromopicolinate; With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 120 ℃; for 3h;

With hydrogenchloride; In water; pH=4;

upstream raw materials:

5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyrimidin-2-ylamine

methyl 5-bromopicolinate

Refernces