N-(4-{N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-(cyanomethyl)amino}-2-fluorobenzoyl)-L-glutamic acid

Base Information

Chemical Name:N-(4-{N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-(cyanomethyl)amino}-2-fluorobenzoyl)-L-glutamic acid
CAS No.:129175-22-0
Molecular Formula:C₂₄H₂₂FN₅O₆
Molecular Weight:495.467
Hs Code.:

Synonyms:N-(4-{N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-(cyanomethyl)amino}-2-fluorobenzoyl)-L-glutamic acid

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Chemical Property of N-(4-{N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-(cyanomethyl)amino}-2-fluorobenzoyl)-L-glutamic acid

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Technology Process of N-(4-{N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-(cyanomethyl)amino}-2-fluorobenzoyl)-L-glutamic acid

There total 4 articles about N-(4-{N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-(cyanomethyl)amino}-2-fluorobenzoyl)-L-glutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 129175-61-7
(S)-2-{4-[Cyanomethyl-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-2-fluoro-benzoylamino}-pentanedioic acid di-tert-butyl ester

: 129175-22-0
N-(4-{N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-(cyanomethyl)amino}-2-fluorobenzoyl)-L-glutamic acid

Guidance literature:: With trifluoroacetic acid; for 0.166667h;
DOI:10.1021/jm00173a026

Reference yield:

: 85803-27-6
di-tert-butyl N-(4-amino-2-fluorobenzoyl)-L-glutamate

: 129175-22-0
N-(4-{N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-(cyanomethyl)amino}-2-fluorobenzoyl)-L-glutamic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / NaI, 2,6-lutidine / dimethylformamide / 3 h / 95 °C

2: 20 percent / CaCO₃ / N,N-dimethyl-acetamide / 24 h / 50 °C

3: 84 percent / CF₃CO₂H / 0.17 h

With 2,6-dimethylpyridine; trifluoroacetic acid; calcium carbonate; sodium iodide; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm00173a026

Reference yield:

: 129175-68-4
(S)-2-[4-(Cyanomethyl-amino)-2-fluoro-benzoylamino]-pentanedioic acid di-tert-butyl ester

: 129175-22-0
N-(4-{N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-(cyanomethyl)amino}-2-fluorobenzoyl)-L-glutamic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 20 percent / CaCO₃ / N,N-dimethyl-acetamide / 24 h / 50 °C

2: 84 percent / CF₃CO₂H / 0.17 h

With trifluoroacetic acid; calcium carbonate; In N,N-dimethyl acetamide;
DOI:10.1021/jm00173a026