(R,Z)-8-(4-(but-2-en-2-yl)pyridin-2-yl)-6-((1-cyclobutylethyl)amino)-7-(4-(trifluoromethyl)benzyl)-7H-purine-2-carboxylic acid

Base Information

Chemical Name:(R,Z)-8-(4-(but-2-en-2-yl)pyridin-2-yl)-6-((1-cyclobutylethyl)amino)-7-(4-(trifluoromethyl)benzyl)-7H-purine-2-carboxylic acid
CAS No.:1621222-44-3
Molecular Formula:C₂₉H₂₉F₃N₆O₂
Molecular Weight:550.583
Hs Code.:

Synonyms:(R,Z)-8-(4-(but-2-en-2-yl)pyridin-2-yl)-6-((1-cyclobutylethyl)amino)-7-(4-(trifluoromethyl)benzyl)-7H-purine-2-carboxylic acid

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Chemical Property of (R,Z)-8-(4-(but-2-en-2-yl)pyridin-2-yl)-6-((1-cyclobutylethyl)amino)-7-(4-(trifluoromethyl)benzyl)-7H-purine-2-carboxylic acid

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Technology Process of (R,Z)-8-(4-(but-2-en-2-yl)pyridin-2-yl)-6-((1-cyclobutylethyl)amino)-7-(4-(trifluoromethyl)benzyl)-7H-purine-2-carboxylic acid

There total 7 articles about (R,Z)-8-(4-(but-2-en-2-yl)pyridin-2-yl)-6-((1-cyclobutylethyl)amino)-7-(4-(trifluoromethyl)benzyl)-7H-purine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1621222-43-2
(R,Z)-8-(4-(but-2-en-2-yl)pyridin-2-yl)-6-((1-cyclobutylethyl)amino)-7-(4-(trifluoromethyl)benzyl)-7H-purine-2-carbonitrile

: 1621222-44-3
(R,Z)-8-(4-(but-2-en-2-yl)pyridin-2-yl)-6-((1-cyclobutylethyl)amino)-7-(4-(trifluoromethyl)benzyl)-7H-purine-2-carboxylic acid

Guidance literature:: With water; sodium hydroxide; In ethanol; at 70 ℃; for 2h;

Reference yield:

: 1621227-19-7
2,6-dichloro-7-(4-(trifluoromethyl)benzyl)-7H-purine

: 1621222-44-3
(R,Z)-8-(4-(but-2-en-2-yl)pyridin-2-yl)-6-((1-cyclobutylethyl)amino)-7-(4-(trifluoromethyl)benzyl)-7H-purine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / isopropyl alcohol / 50 °C

2: XPhos; bis(η3-allyl-μ-chloropalladium(II)) / N,N-dimethyl acetamide / 120 °C / Inert atmosphere

3: catacxium A; palladium diacetate; cesium fluoride; Trimethylacetic acid / 1,4-dioxane / 48 h / 130 °C / Inert atmosphere

4: catacxium A; palladium diacetate; caesium carbonate / 1,4-dioxane; water / 0.17 h / 120 °C / Inert atmosphere; Microwave irradiation

5: sodium hydroxide; water / ethanol / 2 h / 70 °C

With bis(η3-allyl-μ-chloropalladium(II)); water; palladium diacetate; caesium carbonate; triethylamine; cesium fluoride; sodium hydroxide; catacxium A; XPhos; Trimethylacetic acid; In 1,4-dioxane; ethanol; N,N-dimethyl acetamide; water; isopropyl alcohol;

Reference yield:

: 5451-40-1
2,6-dichloro-7H-purine

: 1621222-44-3
(R,Z)-8-(4-(but-2-en-2-yl)pyridin-2-yl)-6-((1-cyclobutylethyl)amino)-7-(4-(trifluoromethyl)benzyl)-7H-purine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: sodium t-butanolate / tetrahydrofuran / Inert atmosphere; Reflux

2: triethylamine / isopropyl alcohol / 50 °C

3: XPhos; bis(η3-allyl-μ-chloropalladium(II)) / N,N-dimethyl acetamide / 120 °C / Inert atmosphere

4: catacxium A; palladium diacetate; cesium fluoride; Trimethylacetic acid / 1,4-dioxane / 48 h / 130 °C / Inert atmosphere

5: catacxium A; palladium diacetate; caesium carbonate / 1,4-dioxane; water / 0.17 h / 120 °C / Inert atmosphere; Microwave irradiation

6: sodium hydroxide; water / ethanol / 2 h / 70 °C

With bis(η3-allyl-μ-chloropalladium(II)); water; palladium diacetate; caesium carbonate; triethylamine; cesium fluoride; sodium hydroxide; sodium t-butanolate; catacxium A; XPhos; Trimethylacetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl acetamide; water; isopropyl alcohol;