(1R,2R,4aS,8aS)-1-(5-ethyl-2,3-diMethoxybenzyl)-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol

Base Information

Chemical Name:(1R,2R,4aS,8aS)-1-(5-ethyl-2,3-diMethoxybenzyl)-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol
CAS No.:849669-49-4
Molecular Formula:C₂₅H₄₀O₃
Molecular Weight:388.591
Hs Code.:

Synonyms:(1R,2R,4aS,8aS)-1-(5-ethyl-2,3-diMethoxybenzyl)-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol

Suppliers and Price of (1R,2R,4aS,8aS)-1-(5-ethyl-2,3-diMethoxybenzyl)-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2R,4aS,8aS)-1-(5-ethyl-2,3-diMethoxybenzyl)-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2R,4aS,8aS)-1-(5-ethyl-2,3-diMethoxybenzyl)-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol

There total 10 articles about (1R,2R,4aS,8aS)-1-(5-ethyl-2,3-diMethoxybenzyl)-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 849669-48-3
(1S,2R,4aS,8aS)-1-[(5-Ethyl-2,3-dimethoxy-phenyl)-hydroxy-methyl]-2,5,5,8a-tetramethyl-decahydro-naphthalen-2-ol

: 849669-49-4
(1R,2R,4aS,8aS)-1-(5-ethyl-2,3-diMethoxybenzyl)-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; under 2250.18 Torr;
DOI:10.1021/ol047316m

Reference yield: 87.0%

: 849669-41-6
1-bromo-2,3-dimethoxy-5-ethylbenzene

: 1376654-39-5
borono-sclareolide

: 849669-49-4
(1R,2R,4aS,8aS)-1-(5-ethyl-2,3-diMethoxybenzyl)-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; cesium fluoride; In 1,4-dioxane; at 50 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ja303937y

Reference yield:

: 564-20-5,1216-84-8,30450-17-0,58976-28-6,64090-92-2,67844-42-2,79768-41-5,79768-42-6,86688-27-9,86688-28-0,95406-08-9,98719-44-9,98719-46-1,131831-65-7,140851-80-5
(3aR)-(+)-sclareolide

: 849669-49-4
(1R,2R,4aS,8aS)-1-(5-ethyl-2,3-diMethoxybenzyl)-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: MeLi / diethyl ether / 20 °C

1.2: (CF₃CO)2O; H₂O₂; NaHCO₃ / CH₂Cl₂ / 20 °C

1.3: 90 percent / KOH / methanol / 20 °C

2.1: 70 percent / (COCl)2; DMSO; Et₃N / 0.33 h / -78 - 20 °C

3.1: t-BuLi / pentane; tetrahydrofuran / 0.5 h / -78 °C

3.2: 63 percent / pentane; tetrahydrofuran / 2 h / -78 °C

4.1: 87 percent / H₂ / Pd/C / ethyl acetate / 20 °C / 2250.18 Torr

With oxalyl dichloride; methyllithium; hydrogen; tert.-butyl lithium; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethyl acetate; pentane; 2.1: Swern oxidation;
DOI:10.1021/ol047316m