ethyl N-[(7-bromo-6-hydroxy-2-oxo-3-phenyl-1,2-dihydro-5-quinoxalinyl)carbonyl]glycinate

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Chemical Name:ethyl N-[(7-bromo-6-hydroxy-2-oxo-3-phenyl-1,2-dihydro-5-quinoxalinyl)carbonyl]glycinate
CAS No.:1160685-98-2
Molecular Formula:C₁₉H₁₆BrN₃O₅
Molecular Weight:446.257
Hs Code.:

Synonyms:ethyl N-[(7-bromo-6-hydroxy-2-oxo-3-phenyl-1,2-dihydro-5-quinoxalinyl)carbonyl]glycinate

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Chemical Property of ethyl N-[(7-bromo-6-hydroxy-2-oxo-3-phenyl-1,2-dihydro-5-quinoxalinyl)carbonyl]glycinate

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Technology Process of ethyl N-[(7-bromo-6-hydroxy-2-oxo-3-phenyl-1,2-dihydro-5-quinoxalinyl)carbonyl]glycinate

There total 7 articles about ethyl N-[(7-bromo-6-hydroxy-2-oxo-3-phenyl-1,2-dihydro-5-quinoxalinyl)carbonyl]glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.37%

: 1160685-97-1
7-bromo-6-hydroxy-2-oxo-3-phenyl-1,2-dihydro-5-quinoxalinecarboxylic acid

: 623-33-6
glycine ethyl ester hydrochloride

: 1160685-98-2
ethyl N-[(7-bromo-6-hydroxy-2-oxo-3-phenyl-1,2-dihydro-5-quinoxalinyl)carbonyl]glycinate

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 13671-00-6
methyl 2,6-difluorobenzoate

: 1160685-98-2
ethyl N-[(7-bromo-6-hydroxy-2-oxo-3-phenyl-1,2-dihydro-5-quinoxalinyl)carbonyl]glycinate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid; nitric acid / 0 - 20 °C

2.1: ammonium hydroxide / ethanol; water / 20 °C

3.1: sodium hydride / mineral oil / 1 h / 0 - 20 °C

4.1: bromine / dichloromethane / 0.5 h / 20 °C

5.1: stannous chloride hydrate; ethanol / ethanol; ethyl acetate; acetonitrile / 3 h / Reflux

5.2: 20 °C

6.1: boron tribromide / dichloromethane / 20 °C

7.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 20 °C

With ammonium hydroxide; stannous chloride hydrate; ethanol; sulfuric acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; bromine; nitric acid; boron tribromide; sodium hydride; triethylamine; In ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 346691-23-4
methyl 2-amino-6-fluoro-3-nitrobenzoate

: 1160685-98-2
ethyl N-[(7-bromo-6-hydroxy-2-oxo-3-phenyl-1,2-dihydro-5-quinoxalinyl)carbonyl]glycinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / mineral oil / 1 h / 0 - 20 °C

2.1: bromine / dichloromethane / 0.5 h / 20 °C

3.1: stannous chloride hydrate; ethanol / ethanol; ethyl acetate; acetonitrile / 3 h / Reflux

3.2: 20 °C

4.1: boron tribromide / dichloromethane / 20 °C

5.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 20 °C

With stannous chloride hydrate; ethanol; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; bromine; boron tribromide; sodium hydride; triethylamine; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; mineral oil;