Ethyl 2-[[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]-4-methylpentanoate

Base Information

Chemical Name:Ethyl 2-[[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]-4-methylpentanoate
CAS No.:181506-74-1
Molecular Formula:C₂₅H₃₄NO₆P
Molecular Weight:475.522
Hs Code.:

Synonyms:Ethyl 2-[[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]-4-methylpentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 2-[[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]-4-methylpentanoate

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Technology Process of Ethyl 2-[[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]-4-methylpentanoate

There total 2 articles about Ethyl 2-[[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.3%

: 87438-94-6
ethyl 2-isobutylacrylate

: 115961-49-4
[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinic acid

: 181506-74-1
Ethyl 2-[[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]-4-methylpentanoate

Guidance literature:: With N,O-bis-(trimethylsilyl)-acetamide;
DOI:10.1021/jm990483l

Reference yield:

: 123803-19-0
ethyl 2-(diethoxyphosphoryl)-4-methylpentanoate

: 181506-74-1
Ethyl 2-[[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]-4-methylpentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 36.7 percent / K₂CO₃ / 3 h / 100 °C

2: 81.3 percent / N,O-bistrimethylsilylacetamide

With N,O-bis-(trimethylsilyl)-acetamide; potassium carbonate; 1: Wittig reaction / 2: Addition;
DOI:10.1021/jm990483l

Reference yield:

: 181506-74-1
Ethyl 2-[[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]-4-methylpentanoate

: 2-Benzyl-3-hydroxy-5-isobutyl-3-oxo-3λ⁵-[1,3]azaphosphinan-6-one

Guidance literature:: Multi-step reaction with 4 steps

1: Ag₂O / CHCl₃ / 1.33 h / Heating

2: 96 percent / H₂ / Pd/C / aq. ethanol / 5 h

3: 4 N NaOH / aq. ethanol / 5 h

4: 60 percent / TFA / CH₂Cl₂ / 1 h

With sodium hydroxide; hydrogen; trifluoroacetic acid; silver(l) oxide; palladium on activated charcoal; In ethanol; dichloromethane; chloroform;
DOI:10.1021/jo9603439