N4-p-bromobenzoyl-N2-(3-methoxypropyl)amino-N1-(2',3'-O-isopropylidene-β-D-ribofuranosyl)-2(1H)-pyrimidinamine hydrochloride

Base Information

Chemical Name:N4-p-bromobenzoyl-N2-(3-methoxypropyl)amino-N1-(2',3'-O-isopropylidene-β-D-ribofuranosyl)-2(1H)-pyrimidinamine hydrochloride
CAS No.:1386977-61-2
Molecular Formula:C₂₃H₂₉BrN₄O₆*ClH
Molecular Weight:573.871
Hs Code.:

Synonyms:N4-p-bromobenzoyl-N2-(3-methoxypropyl)amino-N1-(2',3'-O-isopropylidene-β-D-ribofuranosyl)-2(1H)-pyrimidinamine hydrochloride

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Chemical Property of N4-p-bromobenzoyl-N2-(3-methoxypropyl)amino-N1-(2',3'-O-isopropylidene-β-D-ribofuranosyl)-2(1H)-pyrimidinamine hydrochloride

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Technology Process of N4-p-bromobenzoyl-N2-(3-methoxypropyl)amino-N1-(2',3'-O-isopropylidene-β-D-ribofuranosyl)-2(1H)-pyrimidinamine hydrochloride

There total 5 articles about N4-p-bromobenzoyl-N2-(3-methoxypropyl)amino-N1-(2',3'-O-isopropylidene-β-D-ribofuranosyl)-2(1H)-pyrimidinamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1386977-60-1
N₄-p-bromobenzoyl-2',3'-O-isopropylidene-O₂,5'-cyclocytidine

: 5332-73-0
3-methoxypropylamine

: 1386977-61-2
N4-p-bromobenzoyl-N2-(3-methoxypropyl)amino-N1-(2',3'-O-isopropylidene-β-D-ribofuranosyl)-2(1H)-pyrimidinamine hydrochloride

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In tetrahydrofuran; at 0 ℃; for 0.75h;
DOI:10.1021/ol301769j

Reference yield:

: 1386977-58-7
N₄-p-bromobenzoylcytidine

: 1386977-61-2
N4-p-bromobenzoyl-N2-(3-methoxypropyl)amino-N1-(2',3'-O-isopropylidene-β-D-ribofuranosyl)-2(1H)-pyrimidinamine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: perchloric acid / 1.5 h / 20 °C

1.2: 0.25 h

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / tetrahydrofuran / 0.75 h / 0 °C

With perchloric acid; di-isopropyl azodicarboxylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; lithium chloride; In tetrahydrofuran; dichloromethane; 2.1: Mitsunobu reaction;
DOI:10.1021/ol301769j

Reference yield:

: 1386977-59-8
N₄-p-bromobenzoyl-2',3'-isopropylidenecytidine

: 1386977-61-2
N4-p-bromobenzoyl-N2-(3-methoxypropyl)amino-N1-(2',3'-O-isopropylidene-β-D-ribofuranosyl)-2(1H)-pyrimidinamine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / tetrahydrofuran / 0.75 h / 0 °C

With di-isopropyl azodicarboxylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; lithium chloride; In tetrahydrofuran; dichloromethane; 1: Mitsunobu reaction;
DOI:10.1021/ol301769j