1-methyl-5-(2'-fluoro-4'-nitrophenyl)-2-(3'-thienylcarboxamido)-methyl-2H-1,4-benzodiazepine

Base Information

Chemical Name:1-methyl-5-(2'-fluoro-4'-nitrophenyl)-2-(3'-thienylcarboxamido)-methyl-2H-1,4-benzodiazepine
CAS No.:127648-93-5
Molecular Formula:C₂₂H₁₉FN₄O₃S
Molecular Weight:438.482
Hs Code.:

Synonyms:1-methyl-5-(2'-fluoro-4'-nitrophenyl)-2-(3'-thienylcarboxamido)-methyl-2H-1,4-benzodiazepine

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Chemical Property of 1-methyl-5-(2'-fluoro-4'-nitrophenyl)-2-(3'-thienylcarboxamido)-methyl-2H-1,4-benzodiazepine

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Technology Process of 1-methyl-5-(2'-fluoro-4'-nitrophenyl)-2-(3'-thienylcarboxamido)-methyl-2H-1,4-benzodiazepine

There total 4 articles about 1-methyl-5-(2'-fluoro-4'-nitrophenyl)-2-(3'-thienylcarboxamido)-methyl-2H-1,4-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 41507-35-1
3-thiophene carboxylic acid chloride

: 127648-92-4
C-[5-(2-Fluoro-4-nitro-phenyl)-1-methyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-yl]-methylamine

: 127648-93-5
1-methyl-5-(2'-fluoro-4'-nitrophenyl)-2-(3'-thienylcarboxamido)-methyl-2H-1,4-benzodiazepine

Guidance literature:: With triethylamine; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1016/0223-5234(89)90022-6

Reference yield:

: 88-13-1
3-Thiophene carboxylic acid

: 127648-93-5
1-methyl-5-(2'-fluoro-4'-nitrophenyl)-2-(3'-thienylcarboxamido)-methyl-2H-1,4-benzodiazepine

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / CH₂Cl₂

2: 61 percent / triethylamine / CH₂Cl₂ / 3 h / Ambient temperature

With thionyl chloride; triethylamine; In dichloromethane;
DOI:10.1016/0223-5234(89)90022-6

Reference yield:

: 127648-90-2
2-Chloromethyl-5-(2-fluoro-4-nitro-phenyl)-1-methyl-2,3-dihydro-1H-benzo[e][1,4]diazepine

: 127648-93-5
1-methyl-5-(2'-fluoro-4'-nitrophenyl)-2-(3'-thienylcarboxamido)-methyl-2H-1,4-benzodiazepine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.52 g / KI / methanol / 22 h / Heating

2: 85 percent / 85percent hydrazine hydrate / ethanol / 4.5 h / Heating

3: 61 percent / triethylamine / CH₂Cl₂ / 3 h / Ambient temperature

With hydrazine hydrate; triethylamine; potassium iodide; In methanol; ethanol; dichloromethane;
DOI:10.1016/0223-5234(89)90022-6