1-phenylsulfonyl-3-[(4-(di-tert-butoxycarbonyl)aminomethyl)phenylsulfonyl]indole

Base Information

Chemical Name:1-phenylsulfonyl-3-[(4-(di-tert-butoxycarbonyl)aminomethyl)phenylsulfonyl]indole
CAS No.:170499-50-0
Molecular Formula:C₃₁H₃₄N₂O₈S₂
Molecular Weight:626.752
Hs Code.:

Synonyms:1-phenylsulfonyl-3-[(4-(di-tert-butoxycarbonyl)aminomethyl)phenylsulfonyl]indole

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Chemical Property of 1-phenylsulfonyl-3-[(4-(di-tert-butoxycarbonyl)aminomethyl)phenylsulfonyl]indole

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Technology Process of 1-phenylsulfonyl-3-[(4-(di-tert-butoxycarbonyl)aminomethyl)phenylsulfonyl]indole

There total 6 articles about 1-phenylsulfonyl-3-[(4-(di-tert-butoxycarbonyl)aminomethyl)phenylsulfonyl]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 89004-82-0
potassium bis(tert-butoxycarbonyl)amide

: 170499-49-7
1-phenylsulfonyl-3-[(4-bromomethyl)phenylsulfonyl]indole

: 170499-50-0
1-phenylsulfonyl-3-[(4-(di-tert-butoxycarbonyl)aminomethyl)phenylsulfonyl]indole

Guidance literature:: In N,N-dimethyl-formamide; at 50 ℃; for 2h;
DOI:10.1021/jm970389+

Reference yield:

: 120-72-9
indole

: 170499-50-0
1-phenylsulfonyl-3-[(4-(di-tert-butoxycarbonyl)aminomethyl)phenylsulfonyl]indole

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Et₃N, SO₂Cl₂ / 1.) CH₂Cl₂, -20 deg C, 1 h, 2.) CH₂Cl₂, RT, 17 h

2: 76 percent / KOH / 1,2-dimethoxy-ethane / 1 h

3: 8.15 g / 30percent aq. H₂O₂, glacial acetic acid / 0.5 h / Heating

4: 1.14 g / NBS, benzoyl peroxide / CCl₄ / a) reflux, 3 h, b) RT, 17 h

5: 85 percent / dimethylformamide / 2 h / 50 °C

With potassium hydroxide; N-Bromosuccinimide; sulfuryl dichloride; Perbenzoic acid; dihydrogen peroxide; acetic acid; triethylamine; In tetrachloromethane; 1,2-dimethoxyethane; N,N-dimethyl-formamide;
DOI:10.1021/jm970389+

Reference yield:

: 32884-74-5
3-[(4-methylphenyl)sulfanyl]-1H-indole

: 170499-50-0
1-phenylsulfonyl-3-[(4-(di-tert-butoxycarbonyl)aminomethyl)phenylsulfonyl]indole

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / KOH / 1,2-dimethoxy-ethane / 1 h

2: 8.15 g / 30percent aq. H₂O₂, glacial acetic acid / 0.5 h / Heating

3: 1.14 g / NBS, benzoyl peroxide / CCl₄ / a) reflux, 3 h, b) RT, 17 h

4: 85 percent / dimethylformamide / 2 h / 50 °C

With potassium hydroxide; N-Bromosuccinimide; Perbenzoic acid; dihydrogen peroxide; acetic acid; In tetrachloromethane; 1,2-dimethoxyethane; N,N-dimethyl-formamide;
DOI:10.1021/jm970389+