2,4-NH2Pyrimidin,5(35-ME-4-meo)benzyl

Base Information

Chemical Name:2,4-NH2Pyrimidin,5(35-ME-4-meo)benzyl
CAS No.:73576-30-4
Molecular Formula:C₁₄H₁₈N₄O
Molecular Weight:258.323
Hs Code.:
ChEMBL ID:CHEMBL287553
DSSTox Substance ID:DTXSID00877572
Nikkaji Number:J1.586.473G
Wikidata:Q82859405

Synonyms:CHEMBL287553;73576-30-4;SCHEMBL11643712;DTXSID00877572;BDBM50421786;2,4-NH2PYRIMIDIN,5(35-ME-4-MEO)BENZYL

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Chemical Property of 2,4-NH2Pyrimidin,5(35-ME-4-meo)benzyl

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:258.14806121
Heavy Atom Count:19
Complexity:277

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=CC(=C1OC)C)CC2=CN=C(N=C2N)N

Technology Process of 2,4-NH2Pyrimidin,5(35-ME-4-meo)benzyl

There total 4 articles about 2,4-NH2Pyrimidin,5(35-ME-4-meo)benzyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 73576-27-9
5-(4-Methoxy-3,5-dimethyl-benzyl)-6-methylsulfanyl-pyrimidine-2,4-diamine

: 73576-30-4
2,4-diamino-5-(4-methoxy-3,5-dimethylbenzyl)pyrimidine

Guidance literature:: With Raney nickel W-5; In ethanol; for 6h;
DOI:10.1021/jm00179a012

Reference yield:

: 42900-95-8
4-[(dimethylamino)methyl]-2,6-dimethylphenol

: 73576-30-4
2,4-diamino-5-(4-methoxy-3,5-dimethylbenzyl)pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: ethane-1,2-diol / 120 - 160 °C

2: 1.) NaOMe / 1.) DMSO

3: 35 percent / Raney nickel W-5 / ethanol / 6 h

With Raney nickel W-5; sodium methylate; In ethanol; ethylene glycol;
DOI:10.1021/jm00179a012

Reference yield:

: 73576-39-3
2-Methanesulfonyl-1-(4-methoxy-3,5-dimethyl-phenyl)-ethanol

: 73576-30-4
2,4-diamino-5-(4-methoxy-3,5-dimethylbenzyl)pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: t-BuOK / 2-methyl-propan-2-ol

2: 1.) NaOMe / 1.) EtOH, 2.) EtOH, reflux, 24 h

With potassium tert-butylate; sodium methylate; In tert-butyl alcohol;
DOI:10.1021/jm00179a012