4-(4-bromophenyl)-2-hydrazinyl-6-(thiophen-2-yl)-4,5-dihydropyrimidine

Base Information

• Chemical Name: 4-(4-bromophenyl)-2-hydrazinyl-6-(thiophen-2-yl)-4,5-dihydropyrimidine
• CAS No.: 1228870-92-5
• Molecular Formula: C₁₄H₁₃BrN₄S
• Molecular Weight: 349.254
• Mol file: 1228870-92-5.mol

Synonyms:4-(4-bromophenyl)-2-hydrazinyl-6-(thiophen-2-yl)-4,5-dihydropyrimidine

Chemical Property of 4-(4-bromophenyl)-2-hydrazinyl-6-(thiophen-2-yl)-4,5-dihydropyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-bromophenyl)-2-hydrazinyl-6-(thiophen-2-yl)-4,5-dihydropyrimidine

There total 5 articles about 4-(4-bromophenyl)-2-hydrazinyl-6-(thiophen-2-yl)-4,5-dihydropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-(4-bromophenyl)-2-(ethylthio)-6-(thiophen-2-yl)-4,5-dihydropyrimidine (1228870-90-3) → 4-(4-bromophenyl)-2-hydrazinyl-6-(thiophen-2-yl)-4,5-dihydropyrimidine (1228870-92-5)

Guidance literature:

With hydrazine hydrate; In ethanol; for 4h; Reflux;

DOI:10.1007/s12272-010-0501-1

Reference yield:

3-(4-bromophenyl)-1-(thiophen-2-yl)prop-2-en-1-one (42292-00-2) → 4-(4-bromophenyl)-2-hydrazinyl-6-(thiophen-2-yl)-4,5-dihydropyrimidine (1228870-92-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / ethanol / 6 h / Reflux

2: potassium hydroxide / ethanol; water / 2 h / 60 °C

3: hydrazine hydrate / ethanol / 4 h / Reflux

With hydrazine hydrate; potassium hydroxide; sodium hydroxide; In ethanol; water;

DOI:10.1007/s12272-010-0501-1

Reference yield:

4-bromo-benzaldehyde (1122-91-4) → 4-(4-bromophenyl)-2-hydrazinyl-6-(thiophen-2-yl)-4,5-dihydropyrimidine (1228870-92-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: water; potassium hydroxide / ethanol / 0.5 h / 0 °C

1.2: 20 °C

2.1: sodium hydroxide / ethanol / 6 h / Reflux

3.1: potassium hydroxide / ethanol; water / 2 h / 60 °C

4.1: hydrazine hydrate / ethanol / 4 h / Reflux

With water; hydrazine hydrate; potassium hydroxide; sodium hydroxide; In ethanol; water;

DOI:10.1007/s12272-010-0501-1

upstream raw materials:

2-Acetylthiophene

6-(4-bromophenyl)-4-(thiophen-2-yl)-5,6-dihydropyrimidin-2(1H)-thione

4-(4-bromophenyl)-2-(ethylthio)-6-(thiophen-2-yl)-4,5-dihydropyrimidine

3-(4-bromophenyl)-1-(thiophen-2-yl)prop-2-en-1-one