N-(4-methylphenyl)-tert-butylamidine

Base Information

• Chemical Name: N-(4-methylphenyl)-tert-butylamidine
• CAS No.: 1021397-53-4
• Molecular Formula: C₁₂H₁₈N₂
• Molecular Weight: 190.288
• Mol file: 1021397-53-4.mol

Synonyms:N-(4-methylphenyl)-tert-butylamidine

Chemical Property of N-(4-methylphenyl)-tert-butylamidine

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of N-(4-methylphenyl)-tert-butylamidine

There total 1 articles about N-(4-methylphenyl)-tert-butylamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

tert-butyl isocyanide (630-18-2) + p-toluidine (106-49-0,12221-03-3) → N-(4-methylphenyl)-tert-butylamidine (1021397-53-4)

Guidance literature:

With aluminium trichloride; at 140 ℃; for 0.666667h;

DOI:10.1002/anie.200705420

Reference yield: 93.0%

Benzyl N-hydroxycarbamate (3426-71-9) + N-(4-methylphenyl)-tert-butylamidine (1021397-53-4) → benzyl 2-(tert-butyl)-6-methyl-1H-benzo[d]imidazole-1-carboxylate

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; potassium tert-butylate; silver carbonate; Trimethylacetic acid; In 1,2-dichloro-ethane; at 100 ℃; for 36h; regioselective reaction;

DOI:10.1021/acs.orglett.8b02057

Reference yield: 87.0%

N-(4-methylphenyl)-tert-butylamidine (1021397-53-4) + 5-chloro-3-phenylanthranil (719-64-2) → (2-((1-(2-benzoyl-4-chlorophenyl)-2-(tert-butyl)-6-methyl-1H-benzo[d]imidazol-4-yl)amino)-5-chlorophenyl)(phenyl)methanone

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; lithium acetate; silver(I) triflimide; at 110 ℃; for 24h; Sealed tube;

DOI:10.1021/acs.orglett.9b01902

upstream raw materials:

tert-butyl isocyanide

p-toluidine

Downstream raw materials:

5-methyl-2-(1,1-dimethylethyl)benzimidazole