1-(4-Fluoro-phenyl)-3,3-dimethyl-5-(4-methylsulfanyl-phenyl)-pentane-1,5-dione

Base Information

• Chemical Name: 1-(4-Fluoro-phenyl)-3,3-dimethyl-5-(4-methylsulfanyl-phenyl)-pentane-1,5-dione
• CAS No.: 159429-78-4
• Molecular Formula: C₂₀H₂₁FO₂S
• Molecular Weight: 344.45
• Mol file: 159429-78-4.mol

Synonyms:1-(4-Fluoro-phenyl)-3,3-dimethyl-5-(4-methylsulfanyl-phenyl)-pentane-1,5-dione

Chemical Property of 1-(4-Fluoro-phenyl)-3,3-dimethyl-5-(4-methylsulfanyl-phenyl)-pentane-1,5-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-Fluoro-phenyl)-3,3-dimethyl-5-(4-methylsulfanyl-phenyl)-pentane-1,5-dione

There total 3 articles about 1-(4-Fluoro-phenyl)-3,3-dimethyl-5-(4-methylsulfanyl-phenyl)-pentane-1,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

((1-(4-fluorophenyl)vinyl)oxy)trimethylsilane (58518-77-7) + 3-Methyl-1-(4-methylsulfanyl-phenyl)-but-2-en-1-one (159429-75-1) → 1-(4-Fluoro-phenyl)-3,3-dimethyl-5-(4-methylsulfanyl-phenyl)-pentane-1,5-dione (159429-78-4)

Guidance literature:

With titanium tetrachloride; In dichloromethane; at -78 ℃;

DOI:10.1021/jm00049a005

Reference yield:

Trimethyl-[1-(4-methylsulfanyl-phenyl)-vinyloxy]-silane (159429-74-0) → 1-(4-Fluoro-phenyl)-3,3-dimethyl-5-(4-methylsulfanyl-phenyl)-pentane-1,5-dione (159429-78-4)

Guidance literature:

Multi-step reaction with 3 steps

1: titanium(IV) chloride

2: trifluoroacetic anhydride, pyridine / CH₂Cl₂ / 0 °C

3: titanium(IV) chloride / CH₂Cl₂ / -78 °C

With pyridine; titanium tetrachloride; trifluoroacetic anhydride; In dichloromethane;

DOI:10.1021/jm00049a005

Reference yield:

3-Hydroxy-3-methyl-1-(4-methylsulfanyl-phenyl)-butan-1-one (1027313-67-2) → 1-(4-Fluoro-phenyl)-3,3-dimethyl-5-(4-methylsulfanyl-phenyl)-pentane-1,5-dione (159429-78-4)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic anhydride, pyridine / CH₂Cl₂ / 0 °C

2: titanium(IV) chloride / CH₂Cl₂ / -78 °C

With pyridine; titanium tetrachloride; trifluoroacetic anhydride; In dichloromethane;

DOI:10.1021/jm00049a005

upstream raw materials:

((1-(4-fluorophenyl)vinyl)oxy)trimethylsilane

3-Methyl-1-(4-methylsulfanyl-phenyl)-but-2-en-1-one

3-Hydroxy-3-methyl-1-(4-methylsulfanyl-phenyl)-butan-1-one

Trimethyl-[1-(4-methylsulfanyl-phenyl)-vinyloxy]-silane

Downstream raw materials:

1-(2-(4-fluorophenyl)4,4-dimethylcyclopenten-1-yl)-4-(methylsulfonyl)benzene

1-[2-(4-fluorophenyl)-4,4-dimethylcyclopenten-1-yl]-4-(methylthio) benzene