(E)-N-((R)-2-azido-1-{3-[5-(3,3-dimethyl-piperidin-1-yl)-2-methoxy-benzoyl]-phenoxymethyl}-ethyl)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-acrylamide

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Chemical Name:(E)-N-((R)-2-azido-1-{3-[5-(3,3-dimethyl-piperidin-1-yl)-2-methoxy-benzoyl]-phenoxymethyl}-ethyl)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-acrylamide
CAS No.:1160985-50-1
Molecular Formula:C₃₄H₃₇N₇O₄
Molecular Weight:607.712
Hs Code.:

Synonyms:(E)-N-((R)-2-azido-1-{3-[5-(3,3-dimethyl-piperidin-1-yl)-2-methoxy-benzoyl]-phenoxymethyl}-ethyl)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-acrylamide

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Chemical Property of (E)-N-((R)-2-azido-1-{3-[5-(3,3-dimethyl-piperidin-1-yl)-2-methoxy-benzoyl]-phenoxymethyl}-ethyl)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-acrylamide

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Technology Process of (E)-N-((R)-2-azido-1-{3-[5-(3,3-dimethyl-piperidin-1-yl)-2-methoxy-benzoyl]-phenoxymethyl}-ethyl)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-acrylamide

There total 1 articles about (E)-N-((R)-2-azido-1-{3-[5-(3,3-dimethyl-piperidin-1-yl)-2-methoxy-benzoyl]-phenoxymethyl}-ethyl)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

[3-((R)-2-Amino-3-azido-propoxy)-phenyl]-[5-(3,3-dimethyl-piperidin-1-yl)-2-methoxy-phenyl]-methanone dihydrochloride: [3-((R)-2-Amino-3-azido-propoxy)-phenyl]-[5-(3,3-dimethyl-piperidin-1-yl)-2-methoxy-phenyl]-methanone dihydrochloride

: 123530-68-7
3-(2-carboxyethenyl)-1H-pyrrolo<2,3-b>pyridine

: 1160985-50-1
(E)-N-((R)-2-azido-1-{3-[5-(3,3-dimethyl-piperidin-1-yl)-2-methoxy-benzoyl]-phenoxymethyl}-ethyl)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-acrylamide

Guidance literature:: 3-(2-carboxyethenyl)-1H-pyrrolo<2,3-b>pyridine; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

[3-((R)-2-Amino-3-azido-propoxy)-phenyl]-[5-(3,3-dimethyl-piperidin-1-yl)-2-methoxy-phenyl]-methanone dihydrochloride; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 18h;

Reference yield: 68.0%

: 1160985-50-1
(E)-N-((R)-2-azido-1-{3-[5-(3,3-dimethyl-piperidin-1-yl)-2-methoxy-benzoyl]-phenoxymethyl}-ethyl)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-acrylamide

: 1160985-52-3
(E)-N-((R)-2-Azido-1-{3-[5-(3,3-dimethyl-piperidin-1-yl)-2-hydroxy-benzoyl]-phenoxymethyl}-ethyl)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-acrylamide

Guidance literature:: (E)-N-((R)-2-azido-1-{3-[5-(3,3-dimethyl-piperidin-1-yl)-2-methoxy-benzoyl]-phenoxymethyl}-ethyl)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-acrylamide; With boron tribromide; In dichloromethane; at -75 ℃; for 3.5h;

With methanol; In dichloromethane; at -75 - 20 ℃;

With water; sodium hydrogencarbonate;