Chemical Property of 7-[[2-(2-Amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(1-methylpyrrolidin-1-ium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Chemical Property:
- Appearance/Colour:colorless powder
- Melting Point:150 °C
- PSA：203.58000
- LogP:-0.41110
- XLogP3:-0.1
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:10
- Rotatable Bond Count:6
- Exact Mass:480.12496023
- Heavy Atom Count:32
- Complexity:869
- Purity/Quality:
-
99% *data from raw suppliers
Cefepime 95+% *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
36/37/38-42/43
- Safety Statements:
22-26-36/37/39
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C[N+]1(CCCC1)CC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)[O-]
- Recent EU Clinical Trials:Efficacy and safety of different antimicrobial DURATions for the treatment of infections associated with Osteosynthesis
- Recent NIPH Clinical Trials:A Phase II Study of Cefepime Monotherapy for Febrile Neutropenia in Patients with Lung Cancer
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Description
Cefepime is a new fourth-generation parenteral cephalosporine antibiotic launched in
1993 in Sweden and France. Cefepime has broad spectrum antimicrobial activity against
Staphylococcus, Strepfococcus, Pseudomonas, and the Enterobacteriaceae, including many
bacterial isolates that are resistant to commonly used ceftazidime and cefotaxime. Its
efficacy has been demonstrated in the treatment of lower respiratory tract infections
especially pneumonia, intra-abdominal and urinary tract infections, skin and soft tissue
infections, chronic osteomyelitis and in prophylaxis of biliary tract and prostate infections. It
is well tolerated by patients and is reported to exhibit no significant drug interactions.
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Uses
Cefepime is used for bacterial infections caused by microorganisms that are sensitive to
drugs in septicemia, bacteriemia, complicated infections of the upper and lower sections
of the urinary system, pneumonia, pulmonary abscesses, emphysema of the pleura, fever
in patients with neutropenia, and infected skin and soft tissue wounds. Synonyms of this
drug are maxipime, cepim, cepimex, and others.
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Therapeutic Function
Antibiotic
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Clinical Use
Cefepime (Maxipime, Axepin) is a parenteral, β-lactamase–resistant cephalosporin that is chemically and microbiologicallysimilar to cefpirome. It also has a broadantibacterial spectrum, with significant activity against bothGram-positive and Gram-negative bacteria, including streptococci,staphylococci, Pseudomonas spp., and theEnterobacteriaceae. It is active against some bacterial isolatesthat are resistant to ceftazidime. The efficacy of cefepimehas been demonstrated in the treatment of urinary tract infections,lower respiratory tract infections, skin and soft tissueinfections, chronic osteomyelitis, and intra-abdominal andbiliary infections. It is excreted in the urine with a half-life of2.1 hours. It is bound minimally to plasma proteins. Cefepimeis also a fourth-generation cephalosporin. Proprietary name: Maxipime.
Preparation: Injection.
Dosage: Adult, i.m., i.v., 1–6 g per day in 2–3 divided doses.
Available in USA, most of Europe and Japan; not available in the UK.
