2-[3-(4-chlorobenzoyl)-4-(8-chloro-2,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-ylmethyl)-thiophen-2-yl]-isoindole-1,3-dione

Base Information

Chemical Name:2-[3-(4-chlorobenzoyl)-4-(8-chloro-2,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-ylmethyl)-thiophen-2-yl]-isoindole-1,3-dione
CAS No.:1456735-31-1
Molecular Formula:C₃₁H₂₁Cl₂N₃O₃S
Molecular Weight:586.498
Hs Code.:

Synonyms:2-[3-(4-chlorobenzoyl)-4-(8-chloro-2,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-ylmethyl)-thiophen-2-yl]-isoindole-1,3-dione

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Chemical Property of 2-[3-(4-chlorobenzoyl)-4-(8-chloro-2,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-ylmethyl)-thiophen-2-yl]-isoindole-1,3-dione

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Technology Process of 2-[3-(4-chlorobenzoyl)-4-(8-chloro-2,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-ylmethyl)-thiophen-2-yl]-isoindole-1,3-dione

There total 3 articles about 2-[3-(4-chlorobenzoyl)-4-(8-chloro-2,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-ylmethyl)-thiophen-2-yl]-isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1456734-92-1
2-[5-bromo-3-(4-chlorobenzoyl)-4-(8-chloro-2,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-ylmethyl)-thiophen-2-yl]-isoindole-1,3-dione

: 1456735-31-1
2-[3-(4-chlorobenzoyl)-4-(8-chloro-2,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-ylmethyl)-thiophen-2-yl]-isoindole-1,3-dione

Guidance literature:: With palladium 10% on activated carbon; hydrogen; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h; under 3102.97 Torr; Inert atmosphere;
DOI:10.1016/j.ejmech.2013.07.002

Reference yield:

: 1027493-30-6
2-[5-bromo-4-bromomethyl-3-(4-chloro-benzoyl)-thiophen-2-yl]-isoindole-1,3-dione

: 1456735-31-1
2-[3-(4-chlorobenzoyl)-4-(8-chloro-2,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-ylmethyl)-thiophen-2-yl]-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / dichloromethane / 2.08 h / 4 - 20 °C / Inert atmosphere; Cooling with ice

2: triethylamine; palladium 10% on activated carbon; hydrogen / N,N-dimethyl-formamide / 3 h / 20 °C / 3102.97 Torr / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.07.002

Reference yield:

: 19685-84-8
8‐chloro‐2,3,4,5‐tetrahydro‐1H‐pyrido[4,3‐b]indole

: 1456735-31-1
2-[3-(4-chlorobenzoyl)-4-(8-chloro-2,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-ylmethyl)-thiophen-2-yl]-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / dichloromethane / 2.08 h / 4 - 20 °C / Inert atmosphere; Cooling with ice

2: triethylamine; palladium 10% on activated carbon; hydrogen / N,N-dimethyl-formamide / 3 h / 20 °C / 3102.97 Torr / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.07.002