(E)-N-benzyl-N-styrylacetamide

Base Information

• Chemical Name: (E)-N-benzyl-N-styrylacetamide
• CAS No.: 97305-94-7
• Molecular Formula: C₁₇H₁₇NO
• Molecular Weight: 251.328
• Mol file: 97305-94-7.mol

Synonyms:(E)-N-benzyl-N-styrylacetamide

Chemical Property of (E)-N-benzyl-N-styrylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N-benzyl-N-styrylacetamide

There total 2 articles about (E)-N-benzyl-N-styrylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(E)-N-styrylacetamide (1722-84-5,18793-45-8,18793-44-7) + benzyl chloride (100-44-7) → (E)-N-benzyl-N-styrylacetamide (97305-94-7)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 153 ℃; for 24h;

Reference yield: 45.0%

N-(phenylmethyl)acetamide (588-46-5) + bromostyrene (103-64-0,1340-14-3) → (E)-N-benzyl-N-styrylacetamide (97305-94-7)

Guidance literature:

With copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine; In tetrahydrofuran; Schlenk technique; Inert atmosphere; Reflux;

DOI:10.1021/ol400453b

Reference yield: 75.0%

(E)-N-benzyl-N-styrylacetamide (97305-94-7) → N-benzyl-N-(2-phenylethyl)acetamide (100835-73-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; Ambient temperature;

upstream raw materials:

(E)-N-styrylacetamide

benzyl chloride

N-(phenylmethyl)acetamide

bromostyrene

Downstream raw materials:

N-benzyl-N-(2-phenylethyl)acetamide