2-(4-chlorophenylmethylene)-3-(2-morpholinoethoxy)phenyl-6-methoxy-2,3-dihydrobenzofuran-3-ol

Base Information

• Chemical Name: 2-(4-chlorophenylmethylene)-3-(2-morpholinoethoxy)phenyl-6-methoxy-2,3-dihydrobenzofuran-3-ol
• CAS No.: 151825-62-6
• Molecular Formula: C₂₈H₂₈ClNO₅
• Molecular Weight: 493.987

Synonyms:2-(4-chlorophenylmethylene)-3-(2-morpholinoethoxy)phenyl-6-methoxy-2,3-dihydrobenzofuran-3-ol

Chemical Property of 2-(4-chlorophenylmethylene)-3-(2-morpholinoethoxy)phenyl-6-methoxy-2,3-dihydrobenzofuran-3-ol

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Technology Process of 2-(4-chlorophenylmethylene)-3-(2-morpholinoethoxy)phenyl-6-methoxy-2,3-dihydrobenzofuran-3-ol

There total 2 articles about 2-(4-chlorophenylmethylene)-3-(2-morpholinoethoxy)phenyl-6-methoxy-2,3-dihydrobenzofuran-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

n-butyllithium (109-72-8,29786-93-4) + (Z)-2-(4-chlorobenzylidene)-6-methoxybenzofuran-3(2H)-one (139276-17-8) + 1-bromo-4-(2-morpholinoethoxy)benzene (836-59-9) → 2-(4-chlorophenylmethylene)-3-(2-morpholinoethoxy)phenyl-6-methoxy-2,3-dihydrobenzofuran-3-ol (151825-62-6)

Guidance literature:

With ammonium chloride; In tetrahydrofuran;

Reference yield:

2--6-methoxybenzofuranone (87931-11-1) + 1-bromo-4-(2-morpholinoethoxy)benzene (836-59-9) → 2-(4-chlorophenylmethylene)-3-(2-morpholinoethoxy)phenyl-6-methoxy-2,3-dihydrobenzofuran-3-ol (151825-62-6)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1.) THF, -78 deg C, 1 h, 2.) THF, 30 deg C, overnight;

DOI:10.1080/00397919308011285

Reference yield:

2-(4-chlorophenylmethylene)-3-(2-morpholinoethoxy)phenyl-6-methoxy-2,3-dihydrobenzofuran-3-ol (151825-62-6) → 2-(p-Chlorobenzyl)-3-[p-(2-morpholinoethoxy)phenyl]-6-methoxy-benzo[b]furan

Guidance literature:

With lithium aluminium tetrahydride; magnesium bromide; Yield given. Multistep reaction; 1.) Et₂O, RT, 4 h, 2.) Et₂O, RT, overnight;

DOI:10.1080/00397919308011285

upstream raw materials:

2--6-methoxybenzofuranone

1-bromo-4-(2-morpholinoethoxy)benzene

n-butyllithium

(Z)-2-(4-chlorobenzylidene)-6-methoxybenzofuran-3(2H)-one

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