N-[4-({[2-(dimethylamino)-7-ethynylquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide hydrochloride

Base Information

Chemical Name:N-[4-({[2-(dimethylamino)-7-ethynylquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide hydrochloride
CAS No.:1039733-25-9
Molecular Formula:C₂₆H₂₂FN₅O*ClH
Molecular Weight:475.953
Hs Code.:

Synonyms:N-[4-({[2-(dimethylamino)-7-ethynylquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide hydrochloride

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Chemical Property of N-[4-({[2-(dimethylamino)-7-ethynylquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide hydrochloride

Chemical Property:

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Technology Process of N-[4-({[2-(dimethylamino)-7-ethynylquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide hydrochloride

There total 2 articles about N-[4-({[2-(dimethylamino)-7-ethynylquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1039735-26-6
N-[4-({[2-(dimethylamino)-7-ethynylquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide

: 1039733-25-9
N-[4-({[2-(dimethylamino)-7-ethynylquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane;

Reference yield:

: 1039732-64-3
N-[4-({[2-(dimethylamino)-6-iodoquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide

: 1039733-25-9
N-[4-({[2-(dimethylamino)-7-ethynylquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 3 h / 20 °C

1.2: 20 °C

1.3: pH 5 - 6

2.1: hydrogenchloride / 1,4-dioxane

With hydrogenchloride; copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; N,N-dimethyl-formamide;