Technology Process of (2S,3aR,7aR)-1-benzyl 2-methyl 4-oxo-2,3,3a,4,7,7a-hexahydro-1H-indole-1,2-dicarboxylate
There total 4 articles about (2S,3aR,7aR)-1-benzyl 2-methyl 4-oxo-2,3,3a,4,7,7a-hexahydro-1H-indole-1,2-dicarboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydrogencarbonate; Dess-Martin periodane;
In
dichloromethane;
at 0 ℃;
for 2h;
DOI:10.1002/anie.201207307
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.75 h / 20 °C
2.1: dihydrogen peroxide / methanol; water / 0.08 h / 0 °C
2.2: 0.25 h / 0 °C
3.1: hydrazine hydrate; acetic acid / dichloromethane / 11 h / 0 - 20 °C
4.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 2 h / 0 °C
With
dihydrogen peroxide; sodium hydrogencarbonate; Dess-Martin periodane; hydrazine hydrate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
methanol; dichloromethane; water;
3.1: |Wharton Fragmentation / 4.1: |Dess-Martin Oxidation;
DOI:10.1002/anie.201207307
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrazine hydrate; acetic acid / dichloromethane / 11 h / 0 - 20 °C
2: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 2 h / 0 °C
With
sodium hydrogencarbonate; Dess-Martin periodane; hydrazine hydrate; acetic acid;
In
dichloromethane;
1: |Wharton Fragmentation / 2: |Dess-Martin Oxidation;
DOI:10.1002/anie.201207307