2-Thiohydantoin

Base Information

Chemical Name:2-Thiohydantoin
CAS No.:503-87-7
Molecular Formula:C3H4 N2 O S
Molecular Weight:116.144
Hs Code.:2933990090
European Community (EC) Number:207-977-4
NSC Number:11772
UNII:CP2PH1A61R
DSSTox Substance ID:DTXSID2060121
Nikkaji Number:J9.400E
ChEMBL ID:CHEMBL1958109
Mol file:503-87-7.mol

Synonyms:Thiohydantoin;Thiohydantoins

Suppliers and Price of 2-Thiohydantoin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Thiohydantoin
50g
$ 245.00

TRC
2-Thiohydantoin
10g
$ 95.00

Sigma-Aldrich
2-Thiohydantoin 99%
25g
$ 155.00

Medical Isotopes, Inc.
2-Thiohydantoin
1 g
$ 610.00

Matrix Scientific
2-Thiohydantoin 97%
50g
$ 394.00

Matrix Scientific
2-Thiohydantoin 97%
10g
$ 135.00

Matrix Scientific
2-Thiohydantoin 97%
1g
$ 37.00

Crysdot
2-Thioxoimidazolidin-4-one 95+%
500g
$ 843.00

Chemenu
2-Thiohydantoin 95%
500g
$ 788.00

Atlantic Research Chemicals
2-Thiohydantoin 95%
10gm:
$ 74.23

Total 51 raw suppliers

Chemical Property of 2-Thiohydantoin

Chemical Property:

Appearance/Colour:BROWN CRYSTALLINE POWDER
Melting Point:229-231 ºC
Refractive Index:1.6550 (estimate)
Boiling Point:°Cat760mmHg
PKA:8.50±0.10(Predicted)
Flash Point:°C
PSA：73.22000
Density:1.49g/cm³
LogP:-0.35170
Storage Temp.:Room Temperature
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:-1.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:116.00443393
Heavy Atom Count:7
Complexity:122

Purity/Quality:

99%, ^*data from raw suppliers

2-Thiohydantoin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 20/21/22-22
Safety Statements: 36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(=O)NC(=S)N1
Uses Reactant for synthesis of:? ;Drugs with antidiabetic activity1? ;Barbituric acid and thiohydantoin derivatives with antimicrobial activity2? ;Possible anticancer agents3? ;Fibroblast growth factor receptor 1 kinase inhibitors4? ;HIV-1 integrase inhibitors5Reactant for persilylation6 2-Thiohydantoin is a useful synthetic intermediate. It is a reactant for synthesis of drugs with antidiabetic activity, barbituric acid and thiohydantoin derivatives with antimicrobial activity, and possible anticancer agents. Reactant for synthesis of:Drugs with antidiabetic activityBarbituric acid and thiohydantoin derivatives with antimicrobial activityPossible anticancer agentsFibroblast growth factor receptor 1 kinase inhibitorsHIV-1 integrase inhibitorsReactant for persilylation

Technology Process of 2-Thiohydantoin

There total 39 articles about 2-Thiohydantoin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 584-26-9
1-acetyl-2-thiohydantoin

: 503-87-7
2-thiohydantoin

Guidance literature:: With sodium methylate; In methanol; at 0 - 20 ℃; pH=10; Inert atmosphere; Molecular sieve;
DOI:10.1055/s-0030-1260259

Reference yield: 91.0%

: 17356-08-0
thiourea

: 56-40-6,18875-39-3,25718-94-9
glycine

: 503-87-7
2-thiohydantoin

Guidance literature:: for 0.5h; Heating;
DOI:10.3390/11100739

Reference yield: 61.0%

: 131543-46-9,107-22-2
Glyoxal

: 17356-08-0
thiourea

: 503-87-7
2-thiohydantoin

Guidance literature:: Glyoxal; With phosphorus pentoxide; water; at 20 ℃; for 0.0833333h;

thiourea; at 20 ℃; for 0.166667h;
DOI:10.1016/j.tetlet.2011.02.002