4-[5-(4-fluorophenyl)-2-methylphenyl]-5-hydroxy-2,6-dimethyl-3(2 H)-pyridazinone

Base Information

Chemical Name:4-[5-(4-fluorophenyl)-2-methylphenyl]-5-hydroxy-2,6-dimethyl-3(2 H)-pyridazinone
CAS No.:1170329-34-6
Molecular Formula:C₁₉H₁₇FN₂O₂
Molecular Weight:324.355
Hs Code.:

Synonyms:4-[5-(4-fluorophenyl)-2-methylphenyl]-5-hydroxy-2,6-dimethyl-3(2 H)-pyridazinone

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Chemical Property of 4-[5-(4-fluorophenyl)-2-methylphenyl]-5-hydroxy-2,6-dimethyl-3(2 H)-pyridazinone

Chemical Property:

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Technology Process of 4-[5-(4-fluorophenyl)-2-methylphenyl]-5-hydroxy-2,6-dimethyl-3(2 H)-pyridazinone

There total 3 articles about 4-[5-(4-fluorophenyl)-2-methylphenyl]-5-hydroxy-2,6-dimethyl-3(2 H)-pyridazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1246997-02-3
4-(5-bromo-2-methylphenyl)-5-hydroxy-2,6-dimethyl-3(2H)-pyridazinone

: 1765-93-1
4-fluoroboronic acid

: 1170329-34-6
4-[5-(4-fluorophenyl)-2-methylphenyl]-5-hydroxy-2,6-dimethyl-3(2 H)-pyridazinone

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 90 - 100 ℃; for 10h; Inert atmosphere;

Reference yield:

: 1031387-31-1
(5-bromo-2-methylphenyl)acetyl chloride

: 1170329-34-6
4-[5-(4-fluorophenyl)-2-methylphenyl]-5-hydroxy-2,6-dimethyl-3(2 H)-pyridazinone

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / toluene / 2.83 h / 20 °C / cooling with ice

2: potassium tert-butylate / tetrahydrofuran; toluene / 1.25 h / 50 - 55 °C / Inert atmosphere

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 10 h / 90 - 100 °C / Inert atmosphere

With pyridine; potassium tert-butylate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; toluene;

Reference yield:

: 1246997-52-3
ethyl 2-[2-(5-bromo-2-methylphenylacetyl)-2-methylhydrazono]ethyl propanoate

: 1170329-34-6
4-[5-(4-fluorophenyl)-2-methylphenyl]-5-hydroxy-2,6-dimethyl-3(2 H)-pyridazinone

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / tetrahydrofuran; toluene / 1.25 h / 50 - 55 °C / Inert atmosphere

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 10 h / 90 - 100 °C / Inert atmosphere

With potassium tert-butylate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; toluene;