N-benzyl-3-azabicyclo[3.2.1]-8β-(4-chloro)-phenyloctan-8α-ol

Base Information

• Chemical Name: N-benzyl-3-azabicyclo[3.2.1]-8β-(4-chloro)-phenyloctan-8α-ol
• CAS No.: 521944-19-4
• Molecular Formula: C₂₀H₂₂ClNO
• Molecular Weight: 327.854
• Mol file: 521944-19-4.mol

Synonyms:N-benzyl-3-azabicyclo[3.2.1]-8β-(4-chloro)-phenyloctan-8α-ol

Chemical Property of N-benzyl-3-azabicyclo[3.2.1]-8β-(4-chloro)-phenyloctan-8α-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl-3-azabicyclo[3.2.1]-8β-(4-chloro)-phenyloctan-8α-ol

There total 1 articles about N-benzyl-3-azabicyclo[3.2.1]-8β-(4-chloro)-phenyloctan-8α-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(4-chlorphenyl)magnesium bromide (873-77-8) + 3-benzyl-3-aza-bicyclo[3.2.1]octan-8-one (83507-33-9) → N-benzyl-3-azabicyclo[3.2.1]-8β-(4-chloro)-phenyloctan-8α-ol (521944-19-4)

Guidance literature:

In tetrahydrofuran;

DOI:10.1021/jm020410t

Reference yield:

N-benzyl-3-azabicyclo[3.2.1]-8β-(4-chloro)-phenyloctan-8α-ol (521944-19-4) → N-methyl-3-azabicyclo[3.2.1]-8α-(4-chloro)phenyloctane

Guidance literature:

Multi-step reaction with 4 steps

1.1: NaH; imidazole / tetrahydrofuran / Heating

1.2: tetrahydrofuran

1.3: tetrahydrofuran / Heating

2.1: Bu₃SnH; AIBN / benzene / Heating

3.1: chloroethyl chloroformate / 1,2-dichloro-ethane / Heating

3.2: 79 percent / methanol / 1 h / 50 °C

4.1: 81 percent / HCOOH / Heating

With 1H-imidazole; formic acid; 2,2'-azobis(isobutyronitrile); carbonochloridic acid 1-chloro-ethyl ester; tri-n-butyl-tin hydride; sodium hydride; In tetrahydrofuran; 1,2-dichloro-ethane; benzene;

DOI:10.1021/jm020410t

Reference yield:

N-benzyl-3-azabicyclo[3.2.1]-8β-(4-chloro)-phenyloctan-8α-ol (521944-19-4) → N-benzyl-3-azabicyclo[3.2.1]-8α-(4-chloro)phenyloctane (521944-20-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH; imidazole / tetrahydrofuran / Heating

1.2: tetrahydrofuran

1.3: tetrahydrofuran / Heating

2.1: Bu₃SnH; AIBN / benzene / Heating

With 1H-imidazole; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydride; In tetrahydrofuran; benzene;

DOI:10.1021/jm020410t

upstream raw materials:

(4-chlorphenyl)magnesium bromide

3-benzyl-3-aza-bicyclo[3.2.1]octan-8-one

Downstream raw materials:

N-benzyl-3-azabicyclo[3.2.1]-8α-(4-chloro)phenyloctane