Technology Process of (7R)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid
There total 1 articles about (7R)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
ethanol; 1,2-dichloro-ethane;
at 35 ℃;
Solvent;
Temperature;
Reflux;
- Guidance literature:
-
(R)-4,5-dimethoxy-1,2-dihydrocyclobutabenzene-1-carboxylic acid;
With
potassium hydroxide;
In
water;
for 4h;
With
hydrogenchloride;
In
water;
for 0.5h;
Cooling with ice-water bath;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: potassium hydroxide / water / 4 h
1.2: 0.5 h / Cooling with ice-water bath
2.1: ethyl acetate / 1.25 h / 0 °C / Reflux
3.1: hydrogenchloride / dichloromethane; water / 0.08 h
4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
5.1: dichloromethane; water / 0 - 10 °C
6.1: borane-THF / tetrahydrofuran / 20 - 50 °C
6.2: 0.25 h / 0 - 5 °C
6.3: 2.5 h / 0 °C / Reflux
7.1: potassium carbonate; sodium iodide / 1-methyl-pyrrolidin-2-one / 20 - 60 °C / Inert atmosphere
7.2: 2 h / 20 °C
8.1: potassium carbonate / water / 0.08 h
8.2: Inert atmosphere
9.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / water / 6 h / 45 °C / 7500.75 Torr
With
hydrogenchloride; borane-THF; oxalyl dichloride; hydrogen; potassium carbonate; sodium iodide; potassium hydroxide;
palladium 10% on activated carbon; N,N-dimethyl-formamide;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water; ethyl acetate;
