2-{[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}pentanoic acid tert-butyl ester

Base Information

Chemical Name:2-{[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}pentanoic acid tert-butyl ester
CAS No.:1455091-40-3
Molecular Formula:C₂₇H₂₉N₃O₅
Molecular Weight:475.544
Hs Code.:

Synonyms:2-{[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}pentanoic acid tert-butyl ester

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Chemical Property of 2-{[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}pentanoic acid tert-butyl ester

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Technology Process of 2-{[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}pentanoic acid tert-butyl ester

There total 3 articles about 2-{[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}pentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1455091-23-2
1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxylic acid methyl ester

: 1455091-37-8
2-(aminomethyl)pentanoic acid tert-butyl ester HCl salt

: 1455091-40-3
2-{[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}pentanoic acid tert-butyl ester

Guidance literature:: With sodium methylate; In methanol; at 150 ℃; for 2h; Microwave irradiation;

Reference yield:

: 927895-19-0
2-cyanopentanoic acid tert-butyl ester

: 1455091-40-3
2-{[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / methanol / 20 °C

2: sodium methylate / methanol / 2 h / 150 °C / Microwave irradiation

With hydrogen; sodium methylate; In methanol;

Reference yield:

: 1116-98-9
cyanoacetic acid tert-butyl ester

: 1455091-40-3
2-{[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 80 °C

2: hydrogen / methanol / 20 °C

3: sodium methylate / methanol / 2 h / 150 °C / Microwave irradiation

With hydrogen; sodium methylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; N,N-dimethyl-formamide;