1-(4-chlorobenzyl)-3-(4-(4-chlorobenzyloxy)-2-(benzyloxy)phenyl)-1H-pyrazole-5-carboxylic acid

Base Information

Chemical Name:1-(4-chlorobenzyl)-3-(4-(4-chlorobenzyloxy)-2-(benzyloxy)phenyl)-1H-pyrazole-5-carboxylic acid
CAS No.:821780-27-2
Molecular Formula:C₃₁H₂₄Cl₂N₂O₄
Molecular Weight:559.449
Hs Code.:

Synonyms:1-(4-chlorobenzyl)-3-(4-(4-chlorobenzyloxy)-2-(benzyloxy)phenyl)-1H-pyrazole-5-carboxylic acid

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Chemical Property of 1-(4-chlorobenzyl)-3-(4-(4-chlorobenzyloxy)-2-(benzyloxy)phenyl)-1H-pyrazole-5-carboxylic acid

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Technology Process of 1-(4-chlorobenzyl)-3-(4-(4-chlorobenzyloxy)-2-(benzyloxy)phenyl)-1H-pyrazole-5-carboxylic acid

There total 7 articles about 1-(4-chlorobenzyl)-3-(4-(4-chlorobenzyloxy)-2-(benzyloxy)phenyl)-1H-pyrazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 821780-49-8
ethyl 1-(4-chlorobenzyl)-3-(4-(4-chlorobenzyloxy)-2-(benzyloxy)phenyl)-1H-pyrazole-5-carboxylate

: 821780-27-2
1-(4-chlorobenzyl)-3-(4-(4-chlorobenzyloxy)-2-(benzyloxy)phenyl)-1H-pyrazole-5-carboxylic acid

Guidance literature:: With methanol; sodium hydroxide; In tetrahydrofuran; for 0.5h; Reflux;
DOI:10.2174/1573406411309080013

Reference yield:

: 89-84-9
2',4'-dihydroxy-4-acetophenone

: 821780-27-2
1-(4-chlorobenzyl)-3-(4-(4-chlorobenzyloxy)-2-(benzyloxy)phenyl)-1H-pyrazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate; potassium iodide; tetrabutylammomium bromide / acetone / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 50 °C

3: sodium ethanolate / ethanol; tetrahydrofuran / 8 h / Reflux

4: hydrazine hydrate; acetic acid / 8 h / Reflux

5: potassium carbonate / acetone / 2 h / Reflux

6: sodium hydroxide; methanol / tetrahydrofuran / 0.5 h / Reflux

With methanol; tetrabutylammomium bromide; sodium ethanolate; potassium carbonate; hydrazine hydrate; acetic acid; potassium iodide; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.2174/1573406411309080013

Reference yield:

: 104-83-6
1-Chloro-4-(chloromethyl)benzene

: 821780-27-2
1-(4-chlorobenzyl)-3-(4-(4-chlorobenzyloxy)-2-(benzyloxy)phenyl)-1H-pyrazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate; potassium iodide; tetrabutylammomium bromide / acetone / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 50 °C

3: sodium ethanolate / ethanol; tetrahydrofuran / 8 h / Reflux

4: hydrazine hydrate; acetic acid / 8 h / Reflux

5: potassium carbonate / acetone / 2 h / Reflux

6: sodium hydroxide; methanol / tetrahydrofuran / 0.5 h / Reflux

With methanol; tetrabutylammomium bromide; sodium ethanolate; potassium carbonate; hydrazine hydrate; acetic acid; potassium iodide; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.2174/1573406411309080013