1-(2,4-dichloro-3-phenylquinolin-6-yl)-1-(1-methyl-1H-imidazol-5-yl)-1-pyridin-2-ylmethanamine hydrochloride

Base Information

Chemical Name:1-(2,4-dichloro-3-phenylquinolin-6-yl)-1-(1-methyl-1H-imidazol-5-yl)-1-pyridin-2-ylmethanamine hydrochloride
CAS No.:1600563-86-7
Molecular Formula:C₂₅H₁₉Cl₂N₅*ClH
Molecular Weight:496.826
Hs Code.:

Synonyms:1-(2,4-dichloro-3-phenylquinolin-6-yl)-1-(1-methyl-1H-imidazol-5-yl)-1-pyridin-2-ylmethanamine hydrochloride

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Chemical Property of 1-(2,4-dichloro-3-phenylquinolin-6-yl)-1-(1-methyl-1H-imidazol-5-yl)-1-pyridin-2-ylmethanamine hydrochloride

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Technology Process of 1-(2,4-dichloro-3-phenylquinolin-6-yl)-1-(1-methyl-1H-imidazol-5-yl)-1-pyridin-2-ylmethanamine hydrochloride

There total 8 articles about 1-(2,4-dichloro-3-phenylquinolin-6-yl)-1-(1-methyl-1H-imidazol-5-yl)-1-pyridin-2-ylmethanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1600562-81-9
6-bromo-2,4-dichloro-3-phenylquinoline

: 1600562-95-5
2-methyl-N-((1-methyl-1H-imidazol-5-yl)(pyridin-2-yl)methylene)propane-2-sulfinamide

: 1600563-86-7
1-(2,4-dichloro-3-phenylquinolin-6-yl)-1-(1-methyl-1H-imidazol-5-yl)-1-pyridin-2-ylmethanamine hydrochloride

Guidance literature:: 6-bromo-2,4-dichloro-3-phenylquinoline; 2-methyl-N-((1-methyl-1H-imidazol-5-yl)(pyridin-2-yl)methylene)propane-2-sulfinamide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃;

With water; ammonium chloride; In tetrahydrofuran; hexane;

With hydrogenchloride; In 1,4-dioxane; methanol;

Reference yield:

: 452349-62-1
methyl 5-bromo-2-(2-phenylacetamido)benzoate

: 1600563-86-7
1-(2,4-dichloro-3-phenylquinolin-6-yl)-1-(1-methyl-1H-imidazol-5-yl)-1-pyridin-2-ylmethanamine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hexamethyldisilazane / tetrahydrofuran; hexane; water / 4 h / -78 - 20 °C

2: trichlorophosphate / 3.5 h / 107 °C

3: n-butyllithium / tetrahydrofuran; hexane / -78 - 20 °C

With n-butyllithium; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; hexane; water;

Reference yield:

: 1599529-17-5
(1-methyl-1H-imidazol-5-yl)(pyridin-2-yl)methanone

: 1600563-86-7
1-(2,4-dichloro-3-phenylquinolin-6-yl)-1-(1-methyl-1H-imidazol-5-yl)-1-pyridin-2-ylmethanamine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: titanium (IV) ethoxide / tetrahydrofuran / 108 h / 70 °C

2: n-butyllithium / tetrahydrofuran; hexane / -78 - 20 °C

With n-butyllithium; titanium (IV) ethoxide; In tetrahydrofuran; hexane;