5-[chloro-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-methyl]-2-[1-methyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole

Base Information

Chemical Name:5-[chloro-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-methyl]-2-[1-methyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole
CAS No.:1026236-19-0
Molecular Formula:C₂₄H₃₄ClF₂NO₄SSi
Molecular Weight:534.14
Hs Code.:

Synonyms:5-[chloro-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-methyl]-2-[1-methyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole

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Chemical Property of 5-[chloro-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-methyl]-2-[1-methyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole

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Technology Process of 5-[chloro-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-methyl]-2-[1-methyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole

There total 3 articles about 5-[chloro-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-methyl]-2-[1-methyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 362719-42-4
(+/-)-[(3-cyclobutyloxy-4-difluoromethoxy)phenyl]{2-[1-methyl-1-(2-trimethylsilylethoxy)methoxy]ethylthiazol-5-yl}methanol

: 1026236-19-0
5-[chloro-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-methyl]-2-[1-methyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole

Guidance literature:: With pyridine; thionyl chloride; In toluene; at 20 ℃; for 1h;
DOI:10.1021/jm0204542

Reference yield:

: 16077-78-4
2-(1,3-thiazol-2-yl)propan-2-ol

: 1026236-19-0
5-[chloro-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-methyl]-2-[1-methyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 3.28 g / diisopropylethylamine / CH₂Cl₂ / 22 h

2.1: n-BuLi / diethyl ether; hexane / 0.5 h / -78 °C

2.2: 72 percent / diethyl ether; hexane / 0.75 h

3.1: SOCl₂; pyridine / toluene / 1 h / 20 °C

With pyridine; n-butyllithium; thionyl chloride; N-ethyl-N,N-diisopropylamine; In diethyl ether; hexane; dichloromethane; toluene;
DOI:10.1021/jm0204542

Reference yield:

: 362718-78-3
2-(1-methyl-1-{[2-(trimethylsilyl)ethoxy]methoxy}ethyl)thiazole

: 1026236-19-0
5-[chloro-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-methyl]-2-[1-methyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / diethyl ether; hexane / 0.5 h / -78 °C

1.2: 72 percent / diethyl ether; hexane / 0.75 h

2.1: SOCl₂; pyridine / toluene / 1 h / 20 °C

With pyridine; n-butyllithium; thionyl chloride; In diethyl ether; hexane; toluene;
DOI:10.1021/jm0204542