1-<2-((tert-butoxycarbonyl)aminomethyl)phenyl>-1-(3,4-dimethoxyphenyl)-2-propanone

Base Information

• Chemical Name: 1-<2-((tert-butoxycarbonyl)aminomethyl)phenyl>-1-(3,4-dimethoxyphenyl)-2-propanone
• CAS No.: 155955-80-9
• Molecular Formula: C₂₃H₂₉NO₅
• Molecular Weight: 399.487

Synonyms:1-<2-((tert-butoxycarbonyl)aminomethyl)phenyl>-1-(3,4-dimethoxyphenyl)-2-propanone

Chemical Property of 1-<2-((tert-butoxycarbonyl)aminomethyl)phenyl>-1-(3,4-dimethoxyphenyl)-2-propanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<2-((tert-butoxycarbonyl)aminomethyl)phenyl>-1-(3,4-dimethoxyphenyl)-2-propanone

There total 2 articles about 1-<2-((tert-butoxycarbonyl)aminomethyl)phenyl>-1-(3,4-dimethoxyphenyl)-2-propanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ortho-methylbenzylamine (89-93-0) → 1-<2-((tert-butoxycarbonyl)aminomethyl)phenyl>-1-(3,4-dimethoxyphenyl)-2-propanone (155955-80-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / tetrahydrofuran / 4 h / Ambient temperature

2: 1.) sec-BuLi / 1.) THF, cyclohexane, -30 deg C, 10 min, 2.) THF, cyclohexane, from -60 to -30 deg C, 0.5 h

With sec.-butyllithium; In tetrahydrofuran;

DOI:10.1139/v94-005

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 1-<2-((tert-butoxycarbonyl)aminomethyl)phenyl>-1-(3,4-dimethoxyphenyl)-2-propanone (155955-80-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / tetrahydrofuran / 4 h / Ambient temperature

2: 1.) sec-BuLi / 1.) THF, cyclohexane, -30 deg C, 10 min, 2.) THF, cyclohexane, from -60 to -30 deg C, 0.5 h

With sec.-butyllithium; In tetrahydrofuran;

DOI:10.1139/v94-005

Reference yield: 99.0%

1-<2-((tert-butoxycarbonyl)aminomethyl)phenyl>-1-(3,4-dimethoxyphenyl)-2-propanone (155955-80-9) → 2-(tert-butoxycarbonyl)-1,2-dihydro-3-(3,4-dimethoxyphenylmethyl)isoquinoline (155955-83-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 0.5h;

DOI:10.1139/v94-005

upstream raw materials:

ortho-methylbenzylamine

di-tert-butyl dicarbonate

Downstream raw materials:

2-(tert-butoxycarbonyl)-1,2-dihydro-3-(3,4-dimethoxyphenylmethyl)isoquinoline

3-(3,4-dimethoxyphenyl)methyl-1,2,3,4-tetrahydroisoquinoline

3-(3,4-Dimethoxy-benzyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 155955-80-9 1-<2-((tert-butoxycarbonyl)aminomethyl)phenyl>-1-(3,4-dimethoxyphenyl)-2-propanone

Send

Send

Metric Ton KG G Pound L ML

Send

Send