3-[(1S,3R,4S,5R)-3-(2-Acetoxy-ethyl)-2,2,4-trimethyl-5-(2,2,2-trichloro-ethoxycarbonyloxy)-cyclohexyl]-propionic acid ethyl ester

Base Information

Chemical Name:3-[(1S,3R,4S,5R)-3-(2-Acetoxy-ethyl)-2,2,4-trimethyl-5-(2,2,2-trichloro-ethoxycarbonyloxy)-cyclohexyl]-propionic acid ethyl ester
CAS No.:123887-00-3
Molecular Formula:C₂₁H₃₃Cl₃O₇
Molecular Weight:503.848
Hs Code.:

Synonyms:3-[(1S,3R,4S,5R)-3-(2-Acetoxy-ethyl)-2,2,4-trimethyl-5-(2,2,2-trichloro-ethoxycarbonyloxy)-cyclohexyl]-propionic acid ethyl ester

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Chemical Property of 3-[(1S,3R,4S,5R)-3-(2-Acetoxy-ethyl)-2,2,4-trimethyl-5-(2,2,2-trichloro-ethoxycarbonyloxy)-cyclohexyl]-propionic acid ethyl ester

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Technology Process of 3-[(1S,3R,4S,5R)-3-(2-Acetoxy-ethyl)-2,2,4-trimethyl-5-(2,2,2-trichloro-ethoxycarbonyloxy)-cyclohexyl]-propionic acid ethyl ester

There total 8 articles about 3-[(1S,3R,4S,5R)-3-(2-Acetoxy-ethyl)-2,2,4-trimethyl-5-(2,2,2-trichloro-ethoxycarbonyloxy)-cyclohexyl]-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.1%

: 123886-95-3
3-[(1S,3R,4S,5R)-2,2,4-Trimethyl-3-(3-oxo-butyl)-5-(2,2,2-trichloro-ethoxycarbonyloxy)-cyclohexyl]-propionic acid ethyl ester

: 123887-00-3
3-[(1S,3R,4S,5R)-3-(2-Acetoxy-ethyl)-2,2,4-trimethyl-5-(2,2,2-trichloro-ethoxycarbonyloxy)-cyclohexyl]-propionic acid ethyl ester

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In 1,2-dichloro-ethane; at 55 ℃; for 60h;
DOI:10.1248/cpb.36.4722

Reference yield:

: 123886-93-1
ethyl 3-(5α-hydroxy-2,2,4α-trimethyl-3α-(3-oxobutyl)cyclohexan-1α-yl)propionate

: 123887-00-3
3-[(1S,3R,4S,5R)-3-(2-Acetoxy-ethyl)-2,2,4-trimethyl-5-(2,2,2-trichloro-ethoxycarbonyloxy)-cyclohexyl]-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 78.9 percent / triethylamine, 4-dimethylaminopyridine / diethyl ether / 13 h / Ambient temperature

2: 95.1 percent / mCPBA / 1,2-dichloro-ethane / 60 h / 55 °C

With dmap; triethylamine; 3-chloro-benzenecarboperoxoic acid; In diethyl ether; 1,2-dichloro-ethane;
DOI:10.1248/cpb.36.4722

Reference yield:

: 123886-91-9
{(1S,3R,4S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-2,2,4-trimethyl-3-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-cyclohexyl}-methanol

: 123887-00-3
3-[(1S,3R,4S,5R)-3-(2-Acetoxy-ethyl)-2,2,4-trimethyl-5-(2,2,2-trichloro-ethoxycarbonyloxy)-cyclohexyl]-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.35 g / AcONa*3H₂O, PCC / CH₂Cl₂ / 2.5 h / Ambient temperature

2: toluene / 16 h / 100 °C

3: 851 mg / PtO₂/hydrogen / ethyl acetate / 0.5 h / Ambient temperature

4: 1.) p-toluenesulfonic acid / 1.) acetone, rt., 5 h; 2.) EtOH, 50 deg C, 5 h

5: 78.9 percent / triethylamine, 4-dimethylaminopyridine / diethyl ether / 13 h / Ambient temperature

6: 95.1 percent / mCPBA / 1,2-dichloro-ethane / 60 h / 55 °C

With dmap; platinum(IV) oxide; hydrogen; sodium acetate; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; In diethyl ether; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; toluene;
DOI:10.1248/cpb.36.4722