2-(3,4-dimethoxybenzyl)-4-hydroxy-6-methoxy-5-{[(1R,2S,4aS,8aS)-1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl]methyl}isoindolin-1-one

Base Information

Chemical Name:2-(3,4-dimethoxybenzyl)-4-hydroxy-6-methoxy-5-{[(1R,2S,4aS,8aS)-1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl]methyl}isoindolin-1-one
CAS No.:1236125-80-6
Molecular Formula:C₃₃H₄₃NO₅
Molecular Weight:533.708
Hs Code.:

2-(3,4-dimethoxybenzyl)-4-hydroxy-6-methoxy-5-{[(1R,2S,4aS,8aS)-1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl]methyl}isoindolin-1-one

Synonyms:2-(3,4-dimethoxybenzyl)-4-hydroxy-6-methoxy-5-{[(1R,2S,4aS,8aS)-1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl]methyl}isoindolin-1-one

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Chemical Property of 2-(3,4-dimethoxybenzyl)-4-hydroxy-6-methoxy-5-{[(1R,2S,4aS,8aS)-1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl]methyl}isoindolin-1-one

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Technology Process of 2-(3,4-dimethoxybenzyl)-4-hydroxy-6-methoxy-5-{[(1R,2S,4aS,8aS)-1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl]methyl}isoindolin-1-one

There total 5 articles about 2-(3,4-dimethoxybenzyl)-4-hydroxy-6-methoxy-5-{[(1R,2S,4aS,8aS)-1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl]methyl}isoindolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1236125-79-3
2-(3,4-dimethoxybenzyl)-4-hydroxy-6-methoxy-5-{[(1R,2S,4aS,8aS)-1,2,4a-trimethyl-5-(methylene)-decahydronaphthalen-1-yl]methyl}isoindolin-1-one

: 1236125-80-6
2-(3,4-dimethoxybenzyl)-4-hydroxy-6-methoxy-5-{[(1R,2S,4aS,8aS)-1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl]methyl}isoindolin-1-one

Guidance literature:: With rhodium(III) chloride trihydrate; In ethanol; for 24h; Reflux;
DOI:10.1039/c000193g

Reference yield:

: 1236125-74-8
2-(3,4-dimethoxybenzyl)-4-hydroxy-6-methoxy-5-{[(4a'S,5'S,8a'S)-5',8a'-dimethyl-6'-(methylene)-octahydro-2'H-spiro[[1,3]dioxolane-2,1'-naphthalene]-5'-yl]methyl}isoindolin-1-one

: 1236125-80-6
2-(3,4-dimethoxybenzyl)-4-hydroxy-6-methoxy-5-{[(1R,2S,4aS,8aS)-1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl]methyl}isoindolin-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / tetrahydrofuran; water / 17 h / 20 °C

2.1: palladium 10% on activated carbon; hydrogen; triethylamine / methanol / 24 h / 20 °C / 760.05 Torr

3.1: potassium tert-butylate / benzene / 2 h / Inert atmosphere; Reflux

3.2: 5 h / Inert atmosphere; Reflux

4.1: rhodium (III) chloridetrihydrate / ethanol / 24 h / Reflux

With hydrogenchloride; rhodium (III) chloridetrihydrate; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; triethylamine; In tetrahydrofuran; methanol; ethanol; water; benzene; 3.1: Wittig methylenation / 3.2: Wittig methylenation;
DOI:10.1002/ejoc.201100173

Reference yield:

: 1236125-76-0
2-(3,4-dimethoxybenzyl)-4-hydroxy-6-methoxy-5-{[(1S,4aS,8aS)-1,4a-dimethyl-2-methylene-5-oxodecahydronaphthalen-1-yl]methyl}-isoindolin-1-one

: 1236125-80-6
2-(3,4-dimethoxybenzyl)-4-hydroxy-6-methoxy-5-{[(1R,2S,4aS,8aS)-1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl]methyl}isoindolin-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen; triethylamine / methanol / 24 h / 20 °C / 760.05 Torr

2.1: potassium tert-butylate / benzene / 2 h / Inert atmosphere; Reflux

2.2: 5 h / Inert atmosphere; Reflux

3.1: rhodium (III) chloridetrihydrate / ethanol / 24 h / Reflux

With rhodium (III) chloridetrihydrate; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; triethylamine; In methanol; ethanol; benzene; 2.1: Wittig methylenation / 2.2: Wittig methylenation;
DOI:10.1002/ejoc.201100173