(8R)-8-(2-chlorophenyl)-5,6,7,8-tetrahydro-N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Base Information

Chemical Name:(8R)-8-(2-chlorophenyl)-5,6,7,8-tetrahydro-N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine
CAS No.:1314786-48-5
Molecular Formula:C₂₃H₂₃ClN₆O
Molecular Weight:434.928
Hs Code.:

Synonyms:(8R)-8-(2-chlorophenyl)-5,6,7,8-tetrahydro-N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine

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Chemical Property of (8R)-8-(2-chlorophenyl)-5,6,7,8-tetrahydro-N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine

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Technology Process of (8R)-8-(2-chlorophenyl)-5,6,7,8-tetrahydro-N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine

There total 7 articles about (8R)-8-(2-chlorophenyl)-5,6,7,8-tetrahydro-N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1314786-47-4
8-(2-chlorophenyl)-5,6,7,8-tetrahydro-N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine

: 1314786-48-5
(8R)-8-(2-chlorophenyl)-5,6,7,8-tetrahydro-N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine

: 1314786-49-6
(8S)-8-(2-chlorophenyl)-5,6,7,8-tetrahydro-N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Guidance literature:: With Chralpak Diacel OJ; In methanol; carbon dioxide; isopropylamine; Resolution of racemate;

Reference yield:

: 57486-68-7
methyl (2-chlorophenyl)acetate

: 1314786-48-5
(8R)-8-(2-chlorophenyl)-5,6,7,8-tetrahydro-N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine

: 1314786-49-6
(8S)-8-(2-chlorophenyl)-5,6,7,8-tetrahydro-N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.67 h / 0 - 20 °C

1.2: 20 h / 0 - 20 °C

2.1: isopropyl alcohol / 48 h / 145 °C

3.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tert-butyl alcohol / 20 h / 110 °C / Inert atmosphere

4.1: Chralpak Diacel OJ / carbon dioxide; isopropylamine; methanol / Resolution of racemate

With sodium hydride; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In methanol; carbon dioxide; isopropylamine; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil; tert-butyl alcohol;

Reference yield:

: 454-16-0
1-fluoro-2-methoxy-4-nitrobenzene

: 1314786-48-5
(8R)-8-(2-chlorophenyl)-5,6,7,8-tetrahydro-N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine

: 1314786-49-6
(8S)-8-(2-chlorophenyl)-5,6,7,8-tetrahydro-N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / dimethyl sulfoxide / 16 h / 125 °C / Autoclave; Inert atmosphere

2.1: hydrogen; thiophene / palladium 10% on activated carbon / methanol / 3 h / 50 °C

3.1: sodium nitrite; sulfuric acid / acetic acid / 0.5 h / 10 - 20 °C

3.2: 1 h / 20 °C

3.3: Alkaline conditions

4.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tert-butyl alcohol / 20 h / 110 °C / Inert atmosphere

5.1: Chralpak Diacel OJ / carbon dioxide; isopropylamine; methanol / Resolution of racemate

With thiophene; sulfuric acid; hydrogen; potassium carbonate; caesium carbonate; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; XPhos; In methanol; carbon dioxide; acetic acid; dimethyl sulfoxide; isopropylamine; tert-butyl alcohol;