[3aR-[3aα,4α,6a(R*),6aα]]-6-[4-[[1-[(3-chlorothien-2-yl)methyl]propyl][4-methylbenzenesulfonyl]amino]-3-aminopyrid-2-ylamino] N-ethyl tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxole-4-carboxamide

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Chemical Name:[3aR-[3aα,4α,6a(R*),6aα]]-6-[4-[[1-[(3-chlorothien-2-yl)methyl]propyl][4-methylbenzenesulfonyl]amino]-3-aminopyrid-2-ylamino] N-ethyl tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxole-4-carboxamide
CAS No.:280756-73-2
Molecular Formula:C₃₁H₄₀ClN₅O₅S₂
Molecular Weight:662.274
Hs Code.:

[3aR-[3aα,4α,6a(R*),6aα]]-6-[4-[[1-[(3-chlorothien-2-yl)methyl]propyl][4-methylbenzenesulfonyl]amino]-3-aminopyrid-2-ylamino] N-ethyl tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxole-4-carboxamide

Synonyms:[3aR-[3aα,4α,6a(R*),6aα]]-6-[4-[[1-[(3-chlorothien-2-yl)methyl]propyl][4-methylbenzenesulfonyl]amino]-3-aminopyrid-2-ylamino] N-ethyl tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxole-4-carboxamide

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Chemical Property of [3aR-[3aα,4α,6a(R*),6aα]]-6-[4-[[1-[(3-chlorothien-2-yl)methyl]propyl][4-methylbenzenesulfonyl]amino]-3-aminopyrid-2-ylamino] N-ethyl tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxole-4-carboxamide

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Technology Process of [3aR-[3aα,4α,6a(R*),6aα]]-6-[4-[[1-[(3-chlorothien-2-yl)methyl]propyl][4-methylbenzenesulfonyl]amino]-3-aminopyrid-2-ylamino] N-ethyl tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxole-4-carboxamide

There total 4 articles about [3aR-[3aα,4α,6a(R*),6aα]]-6-[4-[[1-[(3-chlorothien-2-yl)methyl]propyl][4-methylbenzenesulfonyl]amino]-3-aminopyrid-2-ylamino] N-ethyl tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 280756-72-1
[3aR-[3aα,4α,6a(R*),6aα]]-6-[4-[[1-[(3-chlorothien-2-yl)methyl]propyl][4-methylbenzenesulfonyl]amino]-3-nitropyrid-2-ylamino] N-ethyl tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxole-4-carboxamide

: 280756-73-2
[3aR-[3aα,4α,6a(R*),6aα]]-6-[4-[[1-[(3-chlorothien-2-yl)methyl]propyl][4-methylbenzenesulfonyl]amino]-3-aminopyrid-2-ylamino] N-ethyl tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxole-4-carboxamide

Guidance literature:: With hydrogen; platinum on activated charcoal; In methanol; ethyl acetate; at 20 ℃; for 24h; under 2585.81 - 2844.39 Torr;
DOI:10.1021/jo001066f

Reference yield:

: 60186-14-3
2,4-difluoro-3-nitropyridine

: 280756-73-2
[3aR-[3aα,4α,6a(R*),6aα]]-6-[4-[[1-[(3-chlorothien-2-yl)methyl]propyl][4-methylbenzenesulfonyl]amino]-3-aminopyrid-2-ylamino] N-ethyl tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butoxide / tetrahydrofuran / 0.25 h / 20 °C

1.2: 83 percent / tetrahydrofuran / 1 h / 65 °C

2.1: 100 percent / potassium carbonate; 1-methyl-2-pyrrolidinone / 1.5 h / 85 °C

3.1: 97 percent / H₂ / platinum on carbon / ethyl acetate; methanol / 24 h / 20 °C / 2585.81 - 2844.39 Torr

With 1-methyl-pyrrolidin-2-one; potassium tert-butylate; hydrogen; potassium carbonate; platinum on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; 1.1: deprotonation / 1.2: Substitution / 2.1: Substitution / 3.1: Hydrogenolysis;
DOI:10.1021/jo001066f

Reference yield:

: 5975-12-2
2,4-dichloro-3-nitro-pyridine

: 280756-73-2
[3aR-[3aα,4α,6a(R*),6aα]]-6-[4-[[1-[(3-chlorothien-2-yl)methyl]propyl][4-methylbenzenesulfonyl]amino]-3-aminopyrid-2-ylamino] N-ethyl tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxole-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 90 percent / potassium fluoride; 1-methyl-2-pyrrolidinone; 18-crown-6 / 2 h / 100 °C

2.1: potassium tert-butoxide / tetrahydrofuran / 0.25 h / 20 °C

2.2: 83 percent / tetrahydrofuran / 1 h / 65 °C

3.1: 100 percent / potassium carbonate; 1-methyl-2-pyrrolidinone / 1.5 h / 85 °C

4.1: 97 percent / H₂ / platinum on carbon / ethyl acetate; methanol / 24 h / 20 °C / 2585.81 - 2844.39 Torr

With 1-methyl-pyrrolidin-2-one; potassium fluoride; 18-crown-6 ether; potassium tert-butylate; hydrogen; potassium carbonate; platinum on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; 1.1: Substitution / 2.1: deprotonation / 2.2: Substitution / 3.1: Substitution / 4.1: Hydrogenolysis;
DOI:10.1021/jo001066f