Methyl (2S,3S)-3-(benzyloxycarbonylamino)-2-methyl-4-phenyl-2-(prop-2-enyl)butanoate

Base Information

Chemical Name:Methyl (2S,3S)-3-(benzyloxycarbonylamino)-2-methyl-4-phenyl-2-(prop-2-enyl)butanoate
CAS No.:170116-39-9
Molecular Formula:C₂₃H₂₇NO₄
Molecular Weight:381.472
Hs Code.:

Synonyms:Methyl (2S,3S)-3-(benzyloxycarbonylamino)-2-methyl-4-phenyl-2-(prop-2-enyl)butanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl (2S,3S)-3-(benzyloxycarbonylamino)-2-methyl-4-phenyl-2-(prop-2-enyl)butanoate

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Technology Process of Methyl (2S,3S)-3-(benzyloxycarbonylamino)-2-methyl-4-phenyl-2-(prop-2-enyl)butanoate

There total 1 articles about Methyl (2S,3S)-3-(benzyloxycarbonylamino)-2-methyl-4-phenyl-2-(prop-2-enyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 106-95-6
allyl bromide

: 170116-36-6
Methyl (2S,3S)-3-(benzyloxycarbonylamino)-2-methyl-4-phenylbutanoate

: 170116-39-9
Methyl (2S,3S)-3-(benzyloxycarbonylamino)-2-methyl-4-phenyl-2-(prop-2-enyl)butanoate

Guidance literature:: With n-butyllithium; diisopropylamine; lithium chloride; Yield given. Multistep reaction; 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C, 16 h;

Reference yield: 97.0%

: 170116-39-9
Methyl (2S,3S)-3-(benzyloxycarbonylamino)-2-methyl-4-phenyl-2-(prop-2-enyl)butanoate

: 922520-73-8
(S)-2-((S)-1-Benzyloxycarbonylamino-2-phenyl-ethyl)-2-methyl-pent-4-enoic acid

Guidance literature:: With sodium hydroxide; In methanol; for 4h; Heating;
DOI:10.1016/j.jorganchem.2006.09.061

Reference yield:

: 170116-39-9
Methyl (2S,3S)-3-(benzyloxycarbonylamino)-2-methyl-4-phenyl-2-(prop-2-enyl)butanoate

: (1S,3S)-[1-(3-methyl-2-oxo-1,2,3,4-tetrahydropyridin-3-yl)-2-phenylethyl]carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / aq. sodium hydroxide / methanol / 4 h / Heating

2: 71 percent / HOBt; diisopropylethylamine; EDC / CH₂Cl₂ / 16 h / 20 °C

3: 88 percent / [Cl₂(PCy₃)(IMes)Ru(:CHPh)] / benzene / 4 h / Heating

With sodium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; [Cl₂(PCy₃)(IMes)Ru(:CHPh)]; In methanol; dichloromethane; benzene;
DOI:10.1016/j.jorganchem.2006.09.061