8-benzyl-6-propyl-8,9-dihydro-5H-[1,3]dioxolo[4',5':4,5]-benzo[1,2-c]azepin-7(6H)-one

Base Information

Chemical Name:8-benzyl-6-propyl-8,9-dihydro-5H-[1,3]dioxolo[4',5':4,5]-benzo[1,2-c]azepin-7(6H)-one
CAS No.:1373333-23-3
Molecular Formula:C₂₁H₂₃NO₃
Molecular Weight:337.419
Hs Code.:

Synonyms:8-benzyl-6-propyl-8,9-dihydro-5H-[1,3]dioxolo[4',5':4,5]-benzo[1,2-c]azepin-7(6H)-one

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Chemical Property of 8-benzyl-6-propyl-8,9-dihydro-5H-[1,3]dioxolo[4',5':4,5]-benzo[1,2-c]azepin-7(6H)-one

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Technology Process of 8-benzyl-6-propyl-8,9-dihydro-5H-[1,3]dioxolo[4',5':4,5]-benzo[1,2-c]azepin-7(6H)-one

There total 4 articles about 8-benzyl-6-propyl-8,9-dihydro-5H-[1,3]dioxolo[4',5':4,5]-benzo[1,2-c]azepin-7(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1373332-87-6
6-propyl-8,9-dihydro-5H-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]-azepin-7(6H)-one

: 620-05-3
iodomethylbenzene

: 1373333-23-3
8-benzyl-6-propyl-8,9-dihydro-5H-[1,3]dioxolo[4',5':4,5]-benzo[1,2-c]azepin-7(6H)-one

Guidance literature:: 6-propyl-8,9-dihydro-5H-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]-azepin-7(6H)-one; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h;

iodomethylbenzene; In tetrahydrofuran; at -78 - 20 ℃; for 2.5h;
DOI:10.1021/jo300380z

Reference yield:

: 848349-08-6
C₁₃H₁₇NO₃

: 1373333-23-3
8-benzyl-6-propyl-8,9-dihydro-5H-[1,3]dioxolo[4',5':4,5]-benzo[1,2-c]azepin-7(6H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

2.2: 2.5 h / -78 - 20 °C

With trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; 1.1: Friedel Crafts alkylation;
DOI:10.1021/jo300380z

Reference yield:

: 68996-81-6
3-benzo[1,3]dioxol-5-yl-propionyl chloride

: 1373333-23-3
8-benzyl-6-propyl-8,9-dihydro-5H-[1,3]dioxolo[4',5':4,5]-benzo[1,2-c]azepin-7(6H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / dichloromethane; water / 1 h / 0 °C

2.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

3.2: 2.5 h / -78 - 20 °C

With sodium hydrogencarbonate; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; water; 2.1: Friedel Crafts alkylation;
DOI:10.1021/jo300380z