1-[4-cyanobenzyl]-1,4,8,11-tetraazabicyclo[10.2.2]hexadecane

Base Information

• Chemical Name: 1-[4-cyanobenzyl]-1,4,8,11-tetraazabicyclo[10.2.2]hexadecane
• CAS No.: 1400697-01-9
• Molecular Formula: C₂₀H₃₁N₅
• Molecular Weight: 341.5
• Mol file: 1400697-01-9.mol

Synonyms:1-[4-cyanobenzyl]-1,4,8,11-tetraazabicyclo[10.2.2]hexadecane

Chemical Property of 1-[4-cyanobenzyl]-1,4,8,11-tetraazabicyclo[10.2.2]hexadecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[4-cyanobenzyl]-1,4,8,11-tetraazabicyclo[10.2.2]hexadecane

There total 1 articles about 1-[4-cyanobenzyl]-1,4,8,11-tetraazabicyclo[10.2.2]hexadecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3a-(4-cyanobenzyl)-dodecahydro-1H-3a,5a,8a,10a-tetraazapyrenium bromide (1314032-86-4) → 1-[4-cyanobenzyl]-1,4,8,11-tetraazabicyclo[10.2.2]hexadecane (1400697-01-9)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 2.5h; Reflux;

DOI:10.1039/c2dt31137b

Reference yield: 86.0%

1-[4-cyanobenzyl]-1,4,8,11-tetraazabicyclo[10.2.2]hexadecane (1400697-01-9) → 1-[4-aminomethylbenzyl]-1,4,8,11-tetraazabicyclo[10.2.2]hexadecane (1400696-99-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 3.5h; Reflux;

DOI:10.1039/c2dt31137b

Reference yield:

1-[4-cyanobenzyl]-1,4,8,11-tetraazabicyclo[10.2.2]hexadecane (1400697-01-9) → C20H35N5Ni(2+)*2NO3(1-)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / Reflux

2: methanol / 20 - 60 °C / Inert atmosphere

With lithium aluminium tetrahydride; In tetrahydrofuran; methanol;

DOI:10.1039/c2dt31137b

upstream raw materials:

3a-(4-cyanobenzyl)-dodecahydro-1H-3a,5a,8a,10a-tetraazapyrenium bromide

Downstream raw materials:

1-[4-aminomethylbenzyl]-1,4,8,11-tetraazabicyclo[10.2.2]hexadecane