4-[(3-chloro-4-methoxybenzyl)amino]-1-(4-hydroxypiperidino)-6-phthalazinecarboxylic acid

Base Information

Chemical Name:4-[(3-chloro-4-methoxybenzyl)amino]-1-(4-hydroxypiperidino)-6-phthalazinecarboxylic acid
CAS No.:288091-85-0
Molecular Formula:C₂₂H₂₃ClN₄O₄
Molecular Weight:442.902
Hs Code.:

Synonyms:4-[(3-chloro-4-methoxybenzyl)amino]-1-(4-hydroxypiperidino)-6-phthalazinecarboxylic acid

Suppliers and Price of 4-[(3-chloro-4-methoxybenzyl)amino]-1-(4-hydroxypiperidino)-6-phthalazinecarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-[(3-chloro-4-methoxybenzyl)amino]-1-(4-hydroxypiperidino)-6-phthalazinecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-[(3-chloro-4-methoxybenzyl)amino]-1-(4-hydroxypiperidino)-6-phthalazinecarboxylic acid

There total 3 articles about 4-[(3-chloro-4-methoxybenzyl)amino]-1-(4-hydroxypiperidino)-6-phthalazinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 178308-65-1
1-(4-hydroxypiperidino)-4-(3-chloro-4-methoxybenzyl)amino-6-cyanophthalazine

: 288091-85-0
4-[(3-chloro-4-methoxybenzyl)amino]-1-(4-hydroxypiperidino)-6-phthalazinecarboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; for 6h; Heating;
DOI:10.1021/jm9905054

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 288091-85-0
4-[(3-chloro-4-methoxybenzyl)amino]-1-(4-hydroxypiperidino)-6-phthalazinecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: i-Pr₂EtN; NMP / 4.5 h / 170 °C

2: 82 percent / aq. 1N NaOH / methanol / 6 h / Heating

With 1-methyl-pyrrolidin-2-one; sodium hydroxide; N-ethyl-N,N-diisopropylamine; In methanol; 1: Condensation / 2: Hydrolysis;
DOI:10.1021/jm9905054

Reference yield:

: 178308-63-9
1-Chloro-4-(3-chloro-4-methoxybenzyl)amino-6-cyanophthalazine

: 288091-85-0
4-[(3-chloro-4-methoxybenzyl)amino]-1-(4-hydroxypiperidino)-6-phthalazinecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: i-Pr₂EtN; NMP / 4.5 h / 170 °C

2: 82 percent / aq. 1N NaOH / methanol / 6 h / Heating

With 1-methyl-pyrrolidin-2-one; sodium hydroxide; N-ethyl-N,N-diisopropylamine; In methanol; 1: Condensation / 2: Hydrolysis;
DOI:10.1021/jm9905054