1-(4-(2-(5-((3-(2.5.8.11-tetraoxatridecan-13-yloxy)azetidin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea

Base Information

Chemical Name:1-(4-(2-(5-((3-(2.5.8.11-tetraoxatridecan-13-yloxy)azetidin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea
CAS No.:1429340-23-7
Molecular Formula:C₃₅H₄₂FN₅O₇S
Molecular Weight:695.812
Hs Code.:

Synonyms:1-(4-(2-(5-((3-(2.5.8.11-tetraoxatridecan-13-yloxy)azetidin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea

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Chemical Property of 1-(4-(2-(5-((3-(2.5.8.11-tetraoxatridecan-13-yloxy)azetidin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea

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Technology Process of 1-(4-(2-(5-((3-(2.5.8.11-tetraoxatridecan-13-yloxy)azetidin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea

There total 3 articles about 1-(4-(2-(5-((3-(2.5.8.11-tetraoxatridecan-13-yloxy)azetidin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 1187213-95-1
1-cyclopropyl-3-(3-fluoro-4-(2-(5-formylpyridin-2-yl)thieno[3,2-b]-pyridin-7-yloxy)phenyl)urea

: 1429340-36-2
3-(2.5.8.11-tetraoxatridecan-13-yloxy)azetidine

: 1429340-23-7
1-(4-(2-(5-((3-(2.5.8.11-tetraoxatridecan-13-yloxy)azetidin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea

Guidance literature:: 1-cyclopropyl-3-(3-fluoro-4-(2-(5-formylpyridin-2-yl)thieno[3,2-b]-pyridin-7-yloxy)phenyl)urea; 3-(2.5.8.11-tetraoxatridecan-13-yloxy)azetidine; With acetic acid; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1429340-35-1
3-(2.5.8.11-tetraoxatridecan-13-yloxy)-1-benzhydrylazetidine

: 1429340-23-7
1-(4-(2-(5-((3-(2.5.8.11-tetraoxatridecan-13-yloxy)azetidin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea

Guidance literature:: Multi-step reaction with 2 steps

1: palladium(II) hydroxide; hydrogen / ethanol / 5 h / 70 °C

2: acetic acid / dichloromethane; N,N-dimethyl-formamide / 1 h / 20 °C

With hydrogen; palladium(II) hydroxide; acetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 130955-37-2
2-(2-(2-(2-hydroxyethoxy)ethoxy)ethyl) methanesulfonate

: 1429340-23-7
1-(4-(2-(5-((3-(2.5.8.11-tetraoxatridecan-13-yloxy)azetidin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

1.2: 2.5 h / 0 - 60 °C

2.1: palladium(II) hydroxide; hydrogen / ethanol / 5 h / 70 °C

3.1: acetic acid / dichloromethane; N,N-dimethyl-formamide / 1 h / 20 °C

With hydrogen; palladium(II) hydroxide; sodium hydride; acetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;