4-[5-(tert-butyl-diphenyl-silanyloxy)-4-dimethylamino-6-methyl-5,6-dihydro-4H-pyran-2-yl]-4-hydroxy-4H-naphthalen-1-one

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Chemical Name:4-[5-(tert-butyl-diphenyl-silanyloxy)-4-dimethylamino-6-methyl-5,6-dihydro-4H-pyran-2-yl]-4-hydroxy-4H-naphthalen-1-one
CAS No.:862251-54-5
Molecular Formula:C₃₄H₃₉NO₄Si
Molecular Weight:553.773
Hs Code.:

4-[5-(<i>tert</i>-butyl-diphenyl-silanyloxy)-4-dimethylamino-6-methyl-5,6-dihydro-4<i>H</i>-pyran-2-yl]-4-hydroxy-4<i>H</i>-naphthalen-1-one

Synonyms:4-[5-(tert-butyl-diphenyl-silanyloxy)-4-dimethylamino-6-methyl-5,6-dihydro-4H-pyran-2-yl]-4-hydroxy-4H-naphthalen-1-one

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Chemical Property of 4-[5-(tert-butyl-diphenyl-silanyloxy)-4-dimethylamino-6-methyl-5,6-dihydro-4H-pyran-2-yl]-4-hydroxy-4H-naphthalen-1-one

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Technology Process of 4-[5-(tert-butyl-diphenyl-silanyloxy)-4-dimethylamino-6-methyl-5,6-dihydro-4H-pyran-2-yl]-4-hydroxy-4H-naphthalen-1-one

There total 2 articles about 4-[5-(tert-butyl-diphenyl-silanyloxy)-4-dimethylamino-6-methyl-5,6-dihydro-4H-pyran-2-yl]-4-hydroxy-4H-naphthalen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 862251-53-4
[3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-3,4-dihydro-2H-pyran-4-yl]-dimethyl-amine

: 130-15-4
[1,4]naphthoquinone

: 862251-54-5
4-[5-(tert-butyl-diphenyl-silanyloxy)-4-dimethylamino-6-methyl-5,6-dihydro-4H-pyran-2-yl]-4-hydroxy-4H-naphthalen-1-one

Guidance literature:: [3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-3,4-dihydro-2H-pyran-4-yl]-dimethyl-amine; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 - 0 ℃;

[1,4]naphthoquinone; In tetrahydrofuran; pentane; at -78 ℃; for 4.5h;
DOI:10.1081/CAR-200059957

Reference yield:

: 862373-79-3
(3aR,4S,7aR)-1,4-Dimethyl-1,3a,4,7a-tetrahydro-pyrano[4,3-d]oxazol-2-one

: 862251-54-5
4-[5-(tert-butyl-diphenyl-silanyloxy)-4-dimethylamino-6-methyl-5,6-dihydro-4H-pyran-2-yl]-4-hydroxy-4H-naphthalen-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminum hydride / diethyl ether / 2 h / 0 °C

2.1: 1.30 g / 4-(dimethylamino)pyridine; imidazole / dimethylformamide / 15 h

3.1: tert-butyllithium / tetrahydrofuran; pentane / -78 - 0 °C

3.2: 81 percent / tetrahydrofuran; pentane / 4.5 h / -78 °C

With 1H-imidazole; dmap; lithium aluminium tetrahydride; tert.-butyl lithium; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; pentane;
DOI:10.1081/CAR-200059957