phosphoric acid di-tert-butyl ester 3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-octadec-9-enoylamino-propyl ester

Base Information

• Chemical Name: phosphoric acid di-tert-butyl ester 3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-octadec-9-enoylamino-propyl ester
• CAS No.: 851589-01-0
• Molecular Formula: C₄₁H₇₆NO₆PSi
• Molecular Weight: 738.117
• Mol file: 851589-01-0.mol

Synonyms:phosphoric acid di-tert-butyl ester 3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-octadec-9-enoylamino-propyl ester

Chemical Property of phosphoric acid di-tert-butyl ester 3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-octadec-9-enoylamino-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phosphoric acid di-tert-butyl ester 3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-octadec-9-enoylamino-propyl ester

There total 8 articles about phosphoric acid di-tert-butyl ester 3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-octadec-9-enoylamino-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

di-tert-butyl diisopropylphosphoramide (137348-86-8) + (Z)-Octadec-9-enoic acid {(R)-2-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-1-hydroxymethyl-ethyl}-amide (851589-00-9) → phosphoric acid di-tert-butyl ester 3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-octadec-9-enoylamino-propyl ester (851589-01-0)

Guidance literature:

di-tert-butyl diisopropylphosphoramide; (Z)-Octadec-9-enoic acid {(R)-2-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-1-hydroxymethyl-ethyl}-amide; With 1H-tetrazole;

With dihydrogen peroxide;

Reference yield:

D-tyrosine methylester hydrochloride (3728-20-9) → phosphoric acid di-tert-butyl ester 3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-octadec-9-enoylamino-propyl ester (851589-01-0)

Guidance literature:

Multi-step reaction with 5 steps

1: DIEA / CH₂Cl₂ / 4 h

2: DIEA; DMAP / 2 h

3: NaBH₄; CaCl₂ / ethanol; tetrahydrofuran / 18 h

4: tetrazole / 4 h

5: aq. H₂O₂ / 4 h

With 1H-tetrazole; dmap; sodium tetrahydroborate; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; calcium chloride; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2004.05.023

Reference yield:

(R)-3-(4-Hydroxy-phenyl)-2-((Z)-octadec-9-enoylamino)-propionic acid methyl ester (851588-98-2) → phosphoric acid di-tert-butyl ester 3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-octadec-9-enoylamino-propyl ester (851589-01-0)

Guidance literature:

Multi-step reaction with 4 steps

1: DIEA; DMAP / 2 h

2: NaBH₄; CaCl₂ / ethanol; tetrahydrofuran / 18 h

3: tetrazole / 4 h

4: aq. H₂O₂ / 4 h

With 1H-tetrazole; dmap; sodium tetrahydroborate; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; calcium chloride; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bmcl.2004.05.023

upstream raw materials:

di-tert-butyl diisopropylphosphoramide

(Z)-Octadec-9-enoic acid {(R)-2-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-1-hydroxymethyl-ethyl}-amide

(Z)-9-octadecenoyl chloride

D-tyrosine methylester hydrochloride