2-methoxy-5-chloro-N-{5-[1-sulfonylamino-2-ethoxyphenyl]-ethyl}-benzamide

Base Information

Chemical Name:2-methoxy-5-chloro-N-{5-[1-sulfonylamino-2-ethoxyphenyl]-ethyl}-benzamide
CAS No.:158751-84-9
Molecular Formula:C₁₈H₂₁ClN₂O₅S
Molecular Weight:412.894
Hs Code.:

Synonyms:2-methoxy-5-chloro-N-{5-[1-sulfonylamino-2-ethoxyphenyl]-ethyl}-benzamide

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Chemical Property of 2-methoxy-5-chloro-N-{5-[1-sulfonylamino-2-ethoxyphenyl]-ethyl}-benzamide

Chemical Property:

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Technology Process of 2-methoxy-5-chloro-N-{5-[1-sulfonylamino-2-ethoxyphenyl]-ethyl}-benzamide

There total 5 articles about 2-methoxy-5-chloro-N-{5-[1-sulfonylamino-2-ethoxyphenyl]-ethyl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3438-16-2
5-chloro-2-methoxybenzoic acid

: 2-(4-ethoxy-3-sulfamoylphenyl)ethylamine hydrochloride

: 158751-84-9
2-methoxy-5-chloro-N-{5-[1-sulfonylamino-2-ethoxyphenyl]-ethyl}-benzamide

Guidance literature:: With TEA; 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1021/jm000985v

Reference yield:

: 125960-59-0
2-Methoxy-5-(2-(2,2,2-trifluoroacetamido)ethyl)benzenesulfonamide

: 158751-84-9
2-methoxy-5-chloro-N-{5-[1-sulfonylamino-2-ethoxyphenyl]-ethyl}-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / dimethylformamide / 3 h

2: 95 percent / BBr₃ / CH₂Cl₂ / 5 h / 20 °C

3: K₂CO₃ / dimethylformamide / 3 h / 80 °C

4: 5.5N aq. HCl / methanol / 8 h / Heating

5: N,N'-carbonyldiimidazole; TEA / tetrahydrofuran / 12 h / 20 °C

With hydrogenchloride; TEA; boron tribromide; potassium carbonate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm000985v

Reference yield:

: (E)-N-(3-(N-((dimethylamino)methylene)sulfamoyl)-4-methoxyphenethyl)-2,2,2-trifluoroacetamide

: 158751-84-9
2-methoxy-5-chloro-N-{5-[1-sulfonylamino-2-ethoxyphenyl]-ethyl}-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / BBr₃ / CH₂Cl₂ / 5 h / 20 °C

2: K₂CO₃ / dimethylformamide / 3 h / 80 °C

3: 5.5N aq. HCl / methanol / 8 h / Heating

4: N,N'-carbonyldiimidazole; TEA / tetrahydrofuran / 12 h / 20 °C

With hydrogenchloride; TEA; boron tribromide; potassium carbonate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm000985v