7-(4-((1-cyclohexyl-1H-tetrazol-5-yl)(4-methoxynaphthalen-1-yl)methyl)piperazin-1-yl)-6-fluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylicacid

Base Information

Chemical Name:7-(4-((1-cyclohexyl-1H-tetrazol-5-yl)(4-methoxynaphthalen-1-yl)methyl)piperazin-1-yl)-6-fluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylicacid
CAS No.:1604045-10-4
Molecular Formula:C₄₁H₃₉F₄N₇O₄
Molecular Weight:769.799
Hs Code.:

7-(4-((1-cyclohexyl-1H-tetrazol-5-yl)(4-methoxynaphthalen-1-yl)methyl)piperazin-1-yl)-6-fluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylicacid

Synonyms:7-(4-((1-cyclohexyl-1H-tetrazol-5-yl)(4-methoxynaphthalen-1-yl)methyl)piperazin-1-yl)-6-fluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylicacid

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Chemical Property of 7-(4-((1-cyclohexyl-1H-tetrazol-5-yl)(4-methoxynaphthalen-1-yl)methyl)piperazin-1-yl)-6-fluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylicacid

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Technology Process of 7-(4-((1-cyclohexyl-1H-tetrazol-5-yl)(4-methoxynaphthalen-1-yl)methyl)piperazin-1-yl)-6-fluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylicacid

There total 6 articles about 7-(4-((1-cyclohexyl-1H-tetrazol-5-yl)(4-methoxynaphthalen-1-yl)methyl)piperazin-1-yl)-6-fluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₃H₄₃F₄N₇O₄

: 1604045-10-4
7-(4-((1-cyclohexyl-1H-tetrazol-5-yl)(4-methoxynaphthalen-1-yl)methyl)piperazin-1-yl)-6-fluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylicacid

Guidance literature:: With sodium hydroxide; In methanol; water;
DOI:10.1016/j.ejmech.2014.03.069

Reference yield:

: 3863-11-4
3,4-difluoroaniline

: 1604045-10-4
7-(4-((1-cyclohexyl-1H-tetrazol-5-yl)(4-methoxynaphthalen-1-yl)methyl)piperazin-1-yl)-6-fluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylicacid

Guidance literature:: Multi-step reaction with 6 steps

1: 120 °C

2: diphenylether / Reflux

3: sodium hydride / N,N-dimethyl-formamide / 90 °C

4: potassium carbonate / acetonitrile / 90 °C

5: methanol / 0.17 h / 20 °C

6: sodium hydroxide / methanol; water

With sodium hydride; potassium carbonate; sodium hydroxide; In methanol; diphenylether; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2014.03.069

Reference yield:

: 142354-87-8
diethyl 2-[(3,4-difluorophenylamino)methylene]malonate

: 1604045-10-4
7-(4-((1-cyclohexyl-1H-tetrazol-5-yl)(4-methoxynaphthalen-1-yl)methyl)piperazin-1-yl)-6-fluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylicacid

Guidance literature:: Multi-step reaction with 5 steps

1: diphenylether / Reflux

2: sodium hydride / N,N-dimethyl-formamide / 90 °C

3: potassium carbonate / acetonitrile / 90 °C

4: methanol / 0.17 h / 20 °C

5: sodium hydroxide / methanol; water

With sodium hydride; potassium carbonate; sodium hydroxide; In methanol; diphenylether; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2014.03.069