(R)-(5-(3-(3,5-bis-(trifluoromethyl)phenyl)ureido)-6-methoxyquinolin-4-yl)(8-ethylquinuclidin-2-yl)methyl 3,5-bis-(trifluoromethyl)phenylcarbamate

Base Information

Chemical Name:(R)-(5-(3-(3,5-bis-(trifluoromethyl)phenyl)ureido)-6-methoxyquinolin-4-yl)(8-ethylquinuclidin-2-yl)methyl 3,5-bis-(trifluoromethyl)phenylcarbamate
CAS No.:1269656-94-1
Molecular Formula:C₃₈H₃₃F₁₂N₅O₄
Molecular Weight:851.692
Hs Code.:

(R)-(5-(3-(3,5-bis-(trifluoromethyl)phenyl)ureido)-6-methoxyquinolin-4-yl)(8-ethylquinuclidin-2-yl)methyl 3,5-bis-(trifluoromethyl)phenylcarbamate

Synonyms:(R)-(5-(3-(3,5-bis-(trifluoromethyl)phenyl)ureido)-6-methoxyquinolin-4-yl)(8-ethylquinuclidin-2-yl)methyl 3,5-bis-(trifluoromethyl)phenylcarbamate

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Chemical Property of (R)-(5-(3-(3,5-bis-(trifluoromethyl)phenyl)ureido)-6-methoxyquinolin-4-yl)(8-ethylquinuclidin-2-yl)methyl 3,5-bis-(trifluoromethyl)phenylcarbamate

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Technology Process of (R)-(5-(3-(3,5-bis-(trifluoromethyl)phenyl)ureido)-6-methoxyquinolin-4-yl)(8-ethylquinuclidin-2-yl)methyl 3,5-bis-(trifluoromethyl)phenylcarbamate

There total 4 articles about (R)-(5-(3-(3,5-bis-(trifluoromethyl)phenyl)ureido)-6-methoxyquinolin-4-yl)(8-ethylquinuclidin-2-yl)methyl 3,5-bis-(trifluoromethyl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 880147-21-7
(R)-(5-amino-6-methoxyquinolin-4-yl)(8-ethylquinuclidin-2-yl)methanol

: 16588-74-2
3,5-ditrifluoromethylisocyanate

: 1269656-94-1
(R)-(5-(3-(3,5-bis-(trifluoromethyl)phenyl)ureido)-6-methoxyquinolin-4-yl)(8-ethylquinuclidin-2-yl)methyl 3,5-bis-(trifluoromethyl)phenylcarbamate

Guidance literature:: In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/ol103089j

Reference yield:

: 84946-09-8
(R)-(8-ethylquinuclidin-2-yl)(6-methoxy-5-nitroquinolin-4-yl)methanol

: 1269656-94-1
(R)-(5-(3-(3,5-bis-(trifluoromethyl)phenyl)ureido)-6-methoxyquinolin-4-yl)(8-ethylquinuclidin-2-yl)methyl 3,5-bis-(trifluoromethyl)phenylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 5% Pd(II)/C(eggshell); hydrogen / methanol / 3 h / 2280.15 Torr / Inert atmosphere

2: dichloromethane / 16 h / 20 °C / Inert atmosphere

With 5% Pd(II)/C(eggshell); hydrogen; In methanol; dichloromethane;
DOI:10.1021/ol103089j

Reference yield:

: 522-66-7
dihydroquinine

: 1269656-94-1
(R)-(5-(3-(3,5-bis-(trifluoromethyl)phenyl)ureido)-6-methoxyquinolin-4-yl)(8-ethylquinuclidin-2-yl)methyl 3,5-bis-(trifluoromethyl)phenylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: nitric acid / -10 - 5 °C

2: 5% Pd(II)/C(eggshell); hydrogen / methanol / 3 h / 2280.15 Torr / Inert atmosphere

3: dichloromethane / 16 h / 20 °C / Inert atmosphere

With 5% Pd(II)/C(eggshell); hydrogen; nitric acid; In methanol; dichloromethane;
DOI:10.1021/ol103089j