p-methoxybenzyl (Z)-7-((2-tritylamino-thiazol-4-yl)-2-trityloxyimino-acetamido)-3-vinyl-3-cephem-4-carboxylate

Base Information

• Chemical Name: p-methoxybenzyl (Z)-7-((2-tritylamino-thiazol-4-yl)-2-trityloxyimino-acetamido)-3-vinyl-3-cephem-4-carboxylate
• CAS No.: 146667-80-3
• Molecular Formula: C₆₀H₄₉N₅O₆S₂
• Molecular Weight: 1000.21

Synonyms:p-methoxybenzyl (Z)-7-((2-tritylamino-thiazol-4-yl)-2-trityloxyimino-acetamido)-3-vinyl-3-cephem-4-carboxylate

Chemical Property of p-methoxybenzyl (Z)-7-((2-tritylamino-thiazol-4-yl)-2-trityloxyimino-acetamido)-3-vinyl-3-cephem-4-carboxylate

Chemical Property:

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Technology Process of p-methoxybenzyl (Z)-7-((2-tritylamino-thiazol-4-yl)-2-trityloxyimino-acetamido)-3-vinyl-3-cephem-4-carboxylate

There total 1 articles about p-methoxybenzyl (Z)-7-((2-tritylamino-thiazol-4-yl)-2-trityloxyimino-acetamido)-3-vinyl-3-cephem-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-methoxybenzyl 7-amino-3-vinyl-3-cephem-4-carboxylate p-toluenesulfonate salt + sodium 2-(2-tritylaminothiazol-4-yl)-(Z)-2-(tritylhydroxyimino)acetate → p-methoxybenzyl (Z)-7-((2-tritylamino-thiazol-4-yl)-2-trityloxyimino-acetamido)-3-vinyl-3-cephem-4-carboxylate (146667-80-3)

Guidance literature:

p-methoxybenzyl 7-amino-3-vinyl-3-cephem-4-carboxylate p-toluenesulfonate salt; sodium 2-(2-tritylaminothiazol-4-yl)-(Z)-2-(tritylhydroxyimino)acetate; In dichloromethane; at -25 - -20 ℃; for 0.166667h; after azeotropic removal of water;

With pyridine; In dichloromethane; at -25 - -20 ℃; for 0.166667h;

With sodium hydroxide; trichlorophosphate; more than 3 stages;

Reference yield:

p-methoxybenzyl (Z)-7-((2-tritylamino-thiazol-4-yl)-2-trityloxyimino-acetamido)-3-vinyl-3-cephem-4-carboxylate (146667-80-3) → cefdinir (91832-40-5,178601-88-2)

Guidance literature:

p-methoxybenzyl (Z)-7-((2-tritylamino-thiazol-4-yl)-2-trityloxyimino-acetamido)-3-vinyl-3-cephem-4-carboxylate; With trifluoroacetic acid; In toluene; at 5 - 20 ℃; for 3.5h;

With water; In toluene; at 0 - 5 ℃; for 0.75 - 1h;

Downstream raw materials:

cefdinir

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