methyl 4-(3,7-dioxo-2-phenyl-2,3,4,5,6,7-hexahydro-1Hpyrazolo[3,4-c]pyridin-4-yl)benzoate

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Chemical Name:methyl 4-(3,7-dioxo-2-phenyl-2,3,4,5,6,7-hexahydro-1Hpyrazolo[3,4-c]pyridin-4-yl)benzoate
CAS No.:1610360-13-8
Molecular Formula:C₂₀H₁₇N₃O₄
Molecular Weight:363.373
Hs Code.:

Synonyms:methyl 4-(3,7-dioxo-2-phenyl-2,3,4,5,6,7-hexahydro-1Hpyrazolo[3,4-c]pyridin-4-yl)benzoate

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Chemical Property of methyl 4-(3,7-dioxo-2-phenyl-2,3,4,5,6,7-hexahydro-1Hpyrazolo[3,4-c]pyridin-4-yl)benzoate

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Technology Process of methyl 4-(3,7-dioxo-2-phenyl-2,3,4,5,6,7-hexahydro-1Hpyrazolo[3,4-c]pyridin-4-yl)benzoate

There total 2 articles about methyl 4-(3,7-dioxo-2-phenyl-2,3,4,5,6,7-hexahydro-1Hpyrazolo[3,4-c]pyridin-4-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1610360-03-6
ethyl 4-(1-(4-(methoxycarbonyl)phenyl)-2-nitroethyl)-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazole-3-carboxylate

: 1610360-13-8
methyl 4-(3,7-dioxo-2-phenyl-2,3,4,5,6,7-hexahydro-1Hpyrazolo[3,4-c]pyridin-4-yl)benzoate

Guidance literature:: ethyl 4-(1-(4-(methoxycarbonyl)phenyl)-2-nitroethyl)-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazole-3-carboxylate; With acetic acid; zinc; at 20 ℃; for 2h;

With acetic acid; In toluene; at 120 ℃; for 24h;
DOI:10.1021/jo5005795

Reference yield:

: 28710-96-5
5-oxo-1-phenyl-2,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester

: 145344-28-1,115665-98-0
methyl (E)-4-(2’-nitrovinyl)benzoate

: 1610360-13-8
methyl 4-(3,7-dioxo-2-phenyl-2,3,4,5,6,7-hexahydro-1Hpyrazolo[3,4-c]pyridin-4-yl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,4-diaza-bicyclo[2.2.2]octane / dichloromethane / 4 h / 25 °C / Inert atmosphere

2.1: zinc; acetic acid / 2 h / 20 °C

2.2: 24 h / 120 °C

With 1,4-diaza-bicyclo[2.2.2]octane; acetic acid; zinc; In dichloromethane; 1.1: |Michael Addition;
DOI:10.1021/jo5005795