5-nitro-8-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydropyrrolo[2,3-g]indazole

Base Information

Chemical Name:5-nitro-8-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydropyrrolo[2,3-g]indazole
CAS No.:1334218-08-4
Molecular Formula:C₂₀H₁₈N₄O₃
Molecular Weight:362.388
Hs Code.:

Synonyms:5-nitro-8-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydropyrrolo[2,3-g]indazole

Suppliers and Price of 5-nitro-8-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydropyrrolo[2,3-g]indazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-nitro-8-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydropyrrolo[2,3-g]indazole

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-nitro-8-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydropyrrolo[2,3-g]indazole

There total 5 articles about 5-nitro-8-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydropyrrolo[2,3-g]indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1334217-96-7
7-iodo-5-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-amine

: 536-74-3
phenylacetylene

: 1334218-08-4
5-nitro-8-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydropyrrolo[2,3-g]indazole

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; XPhos; In tetrahydrofuran; for 16h; regioselective reaction; Reflux; Inert atmosphere;
DOI:10.1016/j.tet.2011.07.029

Reference yield:

: 1334217-96-7
7-iodo-5-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-amine

: 2170-06-1
1-Phenyl-2-(trimethylsilyl)acetylene

: 1334218-08-4
5-nitro-8-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydropyrrolo[2,3-g]indazole

Guidance literature:: 7-iodo-5-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-amine; 1-Phenyl-2-(trimethylsilyl)acetylene; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; XPhos; In tetrahydrofuran; for 16h; Reflux; Inert atmosphere;

With tetrabutyl ammonium fluoride; regioselective reaction;
DOI:10.1016/j.tet.2011.07.029

Reference yield:

: 1276662-13-5
5,6-dinitro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

: 1334218-08-4
5-nitro-8-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydropyrrolo[2,3-g]indazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 3 h / Reflux

1.2: 1 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; XPhos / tetrahydrofuran / 16 h / Reflux; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; cyclohexa-1,4-diene; palladium 10% on activated carbon; potassium carbonate; XPhos; In tetrahydrofuran; methanol;
DOI:10.1016/j.tet.2011.07.029