2-butyl-5-(t-butyldimethylsilyloxy)methyl-4-iodo-1-<4-(2-cyanophenyl)phenyl>methylimidazole

Base Information

Chemical Name:2-butyl-5-(t-butyldimethylsilyloxy)methyl-4-iodo-1-<4-(2-cyanophenyl)phenyl>methylimidazole
CAS No.:154371-56-9
Molecular Formula:C₂₈H₃₆IN₃OSi
Molecular Weight:585.603
Hs Code.:

Synonyms:2-butyl-5-(t-butyldimethylsilyloxy)methyl-4-iodo-1-<4-(2-cyanophenyl)phenyl>methylimidazole

Suppliers and Price of 2-butyl-5-(t-butyldimethylsilyloxy)methyl-4-iodo-1-<4-(2-cyanophenyl)phenyl>methylimidazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-butyl-5-(t-butyldimethylsilyloxy)methyl-4-iodo-1-<4-(2-cyanophenyl)phenyl>methylimidazole

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Technology Process of 2-butyl-5-(t-butyldimethylsilyloxy)methyl-4-iodo-1-<4-(2-cyanophenyl)phenyl>methylimidazole

There total 8 articles about 2-butyl-5-(t-butyldimethylsilyloxy)methyl-4-iodo-1-<4-(2-cyanophenyl)phenyl>methylimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 124750-35-2
2-butyl-5-hydroxymethyl-4-iodo-1-<4-(2-cyanophenyl)phenyl>methyl-imidazole

: 154371-56-9
2-butyl-5-(t-butyldimethylsilyloxy)methyl-4-iodo-1-<4-(2-cyanophenyl)phenyl>methylimidazole

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; for 2h;
DOI:10.1080/00397919308011184

Reference yield:

: 50790-93-7
2-butyl-1H-imidazole

: 154371-56-9
2-butyl-5-(t-butyldimethylsilyloxy)methyl-4-iodo-1-<4-(2-cyanophenyl)phenyl>methylimidazole

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / iodine, Na₂CO₃ / dioxane; H₂O / 23 h / Ambient temperature

2: 99 percent / K₂CO₃ / dimethylformamide / 19 h

3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 25 min, 2.) THF, hexane, 30 min

4: 98 percent / conc. HCl / aq. ethanol / 1.25 h / Heating

5: 70 percent / K₂CO₃ / dimethylformamide / 60 h

6: 98 percent / NaBH₄ / CH₂Cl₂; ethanol / 0.5 h / 0 °C

7: 91 percent / 2,6-lutidine / CH₂Cl₂ / 2 h

With 2,6-dimethylpyridine; hydrogenchloride; sodium tetrahydroborate; n-butyllithium; iodine; sodium carbonate; potassium carbonate; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1080/00397919308011184

Reference yield:

: 154371-61-6
2-butyl-4,5-diiodoimidazole

: 154371-56-9
2-butyl-5-(t-butyldimethylsilyloxy)methyl-4-iodo-1-<4-(2-cyanophenyl)phenyl>methylimidazole

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / K₂CO₃ / dimethylformamide / 19 h

2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 25 min, 2.) THF, hexane, 30 min

3: 98 percent / conc. HCl / aq. ethanol / 1.25 h / Heating

4: 70 percent / K₂CO₃ / dimethylformamide / 60 h

5: 98 percent / NaBH₄ / CH₂Cl₂; ethanol / 0.5 h / 0 °C

6: 91 percent / 2,6-lutidine / CH₂Cl₂ / 2 h

With 2,6-dimethylpyridine; hydrogenchloride; sodium tetrahydroborate; n-butyllithium; potassium carbonate; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1080/00397919308011184